{"id":"W3212402593","doi":"10.1107/s2059798321010469","title":"<i>Legionella</i> effector LegA15/AnkH contains an unrecognized cysteine protease-like domain and displays structural similarity to LegA3/AnkD, but differs in host cell localization","year":2021,"lang":"en","type":"article","venue":"Acta Crystallographica Section D Structural Biology","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Structural similarity; Effector; Cysteine; Domain (mathematical analysis); Legionella pneumophila; Vacuole; Peptide sequence; Signal peptide; Pathogen; Protein domain","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007574135,0.0003929482,0.0002030741,0.0001968593,0.0001765105,0.0003584226,0.0001993176,0.0003178859,0.001078318],"category_scores_gemma":[0.0001080785,0.00008206256,0.0003587623,0.0002769959,0.0002035422,0.0002872775,0.0002180819,0.0002635949,0.000732606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003748458,"about_ca_system_score_gemma":0.0001576156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005907037,"about_ca_topic_score_gemma":0.0005116091,"domain_scores_codex":[0.9999352,0.00000698469,0.000008133061,0.00001857993,0.00001864372,0.00001258128],"domain_scores_gemma":[0.9999198,0.000007054362,0.00003620454,0.000008813112,0.000008496122,0.00001966418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000148296,0.00002366651,0.001836131,0.00007315826,0.00001149594,0.0002967536,0.00001737126,0.0001265321,0.9935852,0.0002440519,0.0002206169,0.003416833],"study_design_scores_gemma":[0.00002004852,0.0002264682,0.03751187,0.00001899485,0.00002873963,0.00440361,0.00004804577,0.001699649,0.9343302,0.0001987059,0.0214911,0.00002259669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873104,0.002758206,0.004493527,0.0002003093,0.00004575848,0.00002625424,0.002753006,0.0002444516,0.002167981],"genre_scores_gemma":[0.9780232,0.0008875484,0.00631125,0.0001797399,0.00001836566,0.0000263477,0.01090074,0.00003823832,0.003614466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001078318,"threshold_uncertainty_score":0.003607273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00820175182458659,"score_gpt":0.2530210277692467,"score_spread":0.2448192759446601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}