{"id":"W3212402593","doi":"10.1107/s2059798321010469","title":"<i>Legionella</i> effector LegA15/AnkH contains an unrecognized cysteine protease-like domain and displays structural similarity to LegA3/AnkD, but differs in host cell localization","year":2021,"lang":"en","type":"article","venue":"Acta Crystallographica Section D Structural Biology","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Structural similarity; Effector; Cysteine; Domain (mathematical analysis); Legionella pneumophila; Vacuole; Peptide sequence; Signal peptide; Pathogen; Protein domain","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002591696,0.0004701219,0.0004989255,0.0002871831,0.0003734426,0.0001213701,0.0002794853,0.0006278396,0.00003603772],"category_scores_gemma":[0.0001204594,0.0004146039,0.0001578919,0.0006410023,0.0003756521,0.00004593206,0.0002795818,0.0004536953,6.361644e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006171528,"about_ca_system_score_gemma":0.0001268945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007214643,"about_ca_topic_score_gemma":0.002520151,"domain_scores_codex":[0.9966816,0.0007147816,0.000490247,0.00118152,0.0002041868,0.0007276616],"domain_scores_gemma":[0.9986334,0.00006448617,0.0001527061,0.0005103532,0.0002542745,0.0003847948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007557581,0.00004486897,0.07990237,0.00007095119,0.00006487159,0.00004052155,0.0001145261,0.00004433721,0.9186164,0.00004415427,0.0001318774,0.0001694208],"study_design_scores_gemma":[0.02647243,0.01182555,0.5163319,0.0001807432,0.0002559976,0.001978004,0.003093375,0.003439262,0.3485133,0.003300567,0.07955182,0.005057015],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996313,0.0003166744,0.0008184743,0.000651909,0.0005594288,0.001012869,0.000203171,0.00004846251,0.00007597792],"genre_scores_gemma":[0.9963437,0.0001692036,0.0003392299,0.0007324002,0.0003670565,0.00008884193,0.001825279,0.0000461024,0.00008815248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.570103,"threshold_uncertainty_score":0.9998306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00820175182458659,"score_gpt":0.2530210277692467,"score_spread":0.2448192759446601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}