{"id":"W3212434637","doi":"10.1158/1538-7445.panca21-po-077","title":"Abstract PO-077: Establishment of a novel living biobank of patient-derived pancreatic cancer organoids with genomic and drug response characterization","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"FOLFIRINOX; Gemcitabine; Medicine; KRAS; Pancreatic cancer; Irinotecan; Oncology; Internal medicine; Trametinib; Erlotinib; Oxaliplatin; Cancer; Colorectal cancer; Biology; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002387074,0.0003760853,0.0005445544,0.002045294,0.001151284,0.00180838,0.001122264,0.0005217775,0.002612864],"category_scores_gemma":[0.00265022,0.000277003,0.0004044398,0.002307568,0.0006922702,0.0004801787,0.001802787,0.0007246942,0.001511851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002324239,"about_ca_system_score_gemma":0.004436938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02694916,"about_ca_topic_score_gemma":0.02696528,"domain_scores_codex":[0.9987248,0.0001490629,0.0001148271,0.0004062916,0.0004358075,0.0001693687],"domain_scores_gemma":[0.996714,0.0002564451,0.0003071017,0.001050297,0.001066862,0.0006052796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005916846,0.001254806,0.3656068,0.0007618369,0.0004121588,0.002973033,0.003593539,0.005590152,0.3842195,0.005863457,0.03536731,0.1884405],"study_design_scores_gemma":[0.0004350309,0.001775482,0.6102218,0.0001858169,0.000337697,0.004994826,0.002296583,0.007154614,0.1202651,0.001202878,0.2510256,0.0001046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8652823,0.001591449,0.0351464,0.0009718859,0.0001330007,0.003590093,0.08091874,0.0008893238,0.01147688],"genre_scores_gemma":[0.7222517,0.001050193,0.06673766,0.0009030981,0.0001479048,0.003428229,0.1980626,0.0003356481,0.007083032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02694916,"threshold_uncertainty_score":0.05358464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04602365213740525,"score_gpt":0.3666808285077005,"score_spread":0.3206571763702952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}