{"id":"W3212462356","doi":"10.1038/s42003-021-02816-5","title":"G protein-coupled estrogen receptor stimulates human trophoblast cell invasion via YAP-mediated ANGPTL4 expression","year":2021,"lang":"en","type":"article","venue":"Communications Biology","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Zhengzhou University; National Natural Science Foundation of China","keywords":"Trophoblast; ANGPTL4; Cell biology; Estrogen receptor; Protein expression; Estrogen; Receptor; Biology; Chemistry; Endocrinology; Placenta; Genetics; Pregnancy; Gene; Cancer; Fetus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001572801,0.0001834229,0.000367281,0.0001182152,0.00032459,0.00001501515,0.0004439118,0.0002353777,0.0006132555],"category_scores_gemma":[0.0002900029,0.0001566102,0.0001132213,0.0003425777,0.0002718225,0.00006482951,0.0005071177,0.0003173547,0.0002555143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003552972,"about_ca_system_score_gemma":0.0001748625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006083245,"about_ca_topic_score_gemma":0.00002256737,"domain_scores_codex":[0.9985999,0.0003285231,0.0003880826,0.0003186916,0.00008994753,0.0002748951],"domain_scores_gemma":[0.9972531,0.0001694636,0.0001474595,0.002017477,0.0002550988,0.000157418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000049409,0.000524955,0.007022532,0.00003282059,0.0000220561,0.00000154162,0.0001706811,0.000001653379,0.9901283,0.0004175938,0.0006334393,0.0009950445],"study_design_scores_gemma":[0.006346192,0.0005296693,0.005982447,0.0002089554,0.0001739047,0.00002467872,0.0007961274,0.001384891,0.810369,0.001260397,0.1724002,0.0005234817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857066,0.007960946,0.0004144134,0.002013935,0.0001323751,0.000681093,0.00003639812,0.0001586157,0.002895596],"genre_scores_gemma":[0.9788015,0.001028211,0.0157189,0.0003796936,0.00009190865,0.0001579279,0.003184085,0.00003089261,0.000606873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1797592,"threshold_uncertainty_score":0.6714718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02843788487561651,"score_gpt":0.297326326411342,"score_spread":0.2688884415357255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}