{"id":"W3212466554","doi":"10.3390/cancers13215590","title":"Response to FEC Chemotherapy and Oncolytic HSV-1 Is Associated with Macrophage Polarization and Increased Expression of S100A8/A9 in Triple Negative Breast Cancer","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre","funders":"Canadian Cancer Society","keywords":"Oncolytic virus; Cancer research; Triple-negative breast cancer; Immunotherapy; Breast cancer; Medicine; Virotherapy; Gene signature; Immune checkpoint; Gene expression profiling; Chemotherapy; Immune system; Immunology; Gene expression; Cancer; Biology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007550604,0.0001001469,0.0001742472,0.0002370655,0.0001027175,0.0002016491,0.0000490584,0.0001803679,0.0008381571],"category_scores_gemma":[0.000100336,0.00008040504,0.00008611941,0.0001259123,0.0001874012,0.00008006662,0.00008161071,0.0003524483,0.0001383822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001773282,"about_ca_system_score_gemma":0.0001401958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003331025,"about_ca_topic_score_gemma":0.0005495714,"domain_scores_codex":[0.9999094,0.00001160718,0.000006274359,0.0000146405,0.00002703974,0.00003099817],"domain_scores_gemma":[0.9999211,0.00001144414,0.00002054519,0.000007121419,0.000007061857,0.00003278472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004890639,0.00007341822,0.00212702,0.00000857682,0.000003790156,0.00006610801,0.00002387196,0.00003599307,0.995983,0.00002519762,0.00003423227,0.001129805],"study_design_scores_gemma":[0.00004002505,0.002286901,0.2017184,0.000008510748,0.00002408178,0.001330416,0.0002608884,0.001105884,0.7911484,0.0001082703,0.001958928,0.000009359119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992971,0.0001862465,0.00008489792,0.00002833461,0.000006804829,0.000005247254,0.00005964707,0.00000715854,0.0003246057],"genre_scores_gemma":[0.9988751,0.0001175496,0.0001077483,0.00002334274,0.000004011363,0.0000123187,0.0001023252,0.000002237744,0.0007554255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008381571,"threshold_uncertainty_score":0.002803922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008520022860841468,"score_gpt":0.285663344592592,"score_spread":0.2771433217317505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}