{"id":"W3212509541","doi":"10.1182/blood-2021-153237","title":"Single-Cell Profiling Reveals Clinically Relevant Evolutionary Trajectories and Alternate Biologies in Human Follicular Lymphoma","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Spinal Cord Injury BC; Terry Fox Research Institute","funders":"","keywords":"Follicular lymphoma; Biology; Germinal center; CD8; Lymphoma; Immunology; Mass cytometry; B cell; Immune system; Diffuse large B-cell lymphoma; Cytotoxic T cell; Immunophenotyping; Cluster of differentiation; Phenotype; Cell of origin; Flow cytometry; Cell; Antibody; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001600721,0.00007294318,0.0001757253,0.0006448581,0.0001923346,0.0003668687,0.000105085,0.0002395247,0.0006920208],"category_scores_gemma":[0.0003049983,0.00006980264,0.00009441255,0.000381615,0.0001308838,0.0001163544,0.0001613378,0.0001181077,0.0002220625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001802723,"about_ca_system_score_gemma":0.00006697526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001173321,"about_ca_topic_score_gemma":0.001332628,"domain_scores_codex":[0.9999075,0.00001412285,0.000004992513,0.00002908367,0.00002000169,0.00002424881],"domain_scores_gemma":[0.9999071,0.00002307442,0.00001683073,0.00001072956,0.0000239823,0.00001832453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007434517,0.00005813758,0.2408557,0.00005062911,0.00003764683,0.0003693701,0.0006391562,0.001000992,0.7371982,0.0001604564,0.0002315808,0.01865465],"study_design_scores_gemma":[0.00001663535,0.0003827645,0.9079056,0.000008842503,0.00003750464,0.001321608,0.0009330134,0.009004248,0.07812775,0.0004007276,0.0018443,0.00001695533],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985664,0.0001944562,0.0008429012,0.00001214031,0.000001384517,0.000008163669,0.0001793269,0.00001305797,0.000182178],"genre_scores_gemma":[0.9991141,0.00005007969,0.0004895112,0.000009700764,0.00000221963,0.00000843898,0.0001795228,0.000002472397,0.0001438992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001173321,"threshold_uncertainty_score":0.002332985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02715453061176003,"score_gpt":0.2809661847984675,"score_spread":0.2538116541867074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}