{"id":"W3212549159","doi":"10.1101/2021.11.05.467440","title":"Rational Designed Hybrid Peptides Show up to a 6-fold Increase in Antimicrobial Activity and Demonstrate Different Ultrastructural Changes as the Parental Peptides measured by BioSAXS","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bundesministerium für Bildung und Forschung; Institute of Infection and Immunity; Karlsruhe Institute of Technology","keywords":"Antimicrobial peptides; Isoleucine; Peptide; Arginine; Antimicrobial; Biochemistry; Proline; Amino acid; Biology; Chemistry; Leucine; Microbiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001896675,0.0005127833,0.000207423,0.0001451939,0.0001005634,0.0002741858,0.0001221591,0.0003315965,0.001205041],"category_scores_gemma":[0.0001531829,0.0001320939,0.0001815259,0.0001340101,0.0001854792,0.0001996661,0.0001913693,0.0004291042,0.0003871003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001547731,"about_ca_system_score_gemma":0.00005458283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009155378,"about_ca_topic_score_gemma":0.0001651171,"domain_scores_codex":[0.99984,0.00003323584,0.00001580649,0.00002964283,0.000047772,0.00003348466],"domain_scores_gemma":[0.9998726,0.00002671746,0.0000370417,0.00001082282,0.00002413598,0.00002878589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006338477,0.00001477814,0.0000464283,0.00002154698,0.000004578324,0.0000235789,0.000005341833,0.0001063535,0.9991465,0.00002571451,0.00001441845,0.0005273792],"study_design_scores_gemma":[0.000008750573,0.000244442,0.0007892584,0.000003639983,0.0000101577,0.00007559493,0.00001288691,0.000531082,0.9973557,0.00001974418,0.000943967,0.000004884144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937801,0.0008401984,0.003398557,0.0000421198,0.00002598058,0.00003067538,0.0002337585,0.00005787226,0.001590772],"genre_scores_gemma":[0.9910696,0.0003925707,0.006348887,0.00004843625,0.000005302685,0.00005162738,0.0004020539,0.00003468942,0.001646888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001205041,"threshold_uncertainty_score":0.004031241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01175871762100784,"score_gpt":0.2079147039667202,"score_spread":0.1961559863457124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}