{"id":"W3212553475","doi":"10.1136/jitc-2021-sitc2021.466","title":"466 Use of a 27-gene immuno-oncology (IO) assay to associate response to single-agent immune checkpoint inhibitor (ICI) therapy in advanced-stage NSCLC patients from a large Canadian cohort","year":2021,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Oncology; Medicine; Internal medicine; Lung cancer; Cancer; Targeted therapy; Biomarker; Breast cancer; Immunotherapy; Immunohistochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001486518,0.0003986256,0.0008898901,0.0003790064,0.0001221099,0.00007288613,0.0001541894,0.0003567428,0.00008010992],"category_scores_gemma":[0.00175476,0.0003946828,0.0002268255,0.0006351198,0.0001547766,0.0001875513,0.00009242788,0.000316645,0.00001330771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001507959,"about_ca_system_score_gemma":0.002149456,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.04383892,"about_ca_topic_score_gemma":0.03905167,"domain_scores_codex":[0.9965048,0.0004358061,0.00108501,0.0006869292,0.0005248106,0.0007625885],"domain_scores_gemma":[0.9973506,0.0002047101,0.0003144469,0.0006658893,0.0003647592,0.001099537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006072059,0.000558321,0.1199599,0.00003346522,0.0003825294,0.0003714337,0.002666401,0.00003121384,0.865175,0.000003278976,0.0007855837,0.003960821],"study_design_scores_gemma":[0.004434815,0.00080018,0.5732615,0.0004299225,0.00004619399,0.0000146636,0.000326556,0.000007446908,0.3513645,0.00001002785,0.06900817,0.0002960601],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920183,0.00188813,0.000007620456,0.003218171,0.0008448641,0.001247051,0.0006360851,0.00003729755,0.0001024802],"genre_scores_gemma":[0.9932568,0.0003354661,0.001525155,0.00342554,0.00008211556,0.0000744579,0.0003112829,0.00007276627,0.0009164226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5138105,"threshold_uncertainty_score":0.9998505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02346754772782018,"score_gpt":0.2608376512464363,"score_spread":0.2373701035186161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}