{"id":"W3212572680","doi":"10.1182/blood-2021-146003","title":"Clinical Outcomes in Patients (Pts) with Dose Reduction of Selinexor in Combination with Bortezomib, and Dexamethasone (XVd) in Previously Treated Multiple Myeloma from the Boston Study","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Bortezomib; Dexamethasone; Tolerability; Internal medicine; Multiple myeloma; Adverse effect; Population; Discontinuation; Oncology; Neutropenia; Gastroenterology; Pharmacology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001407704,0.0004661224,0.0009144425,0.0003639331,0.0002709768,0.0007264522,0.0004120531,0.0006466511,0.001978926],"category_scores_gemma":[0.0009577756,0.0002126684,0.001314783,0.0004914686,0.0002330547,0.0004621086,0.0005083208,0.0008662794,0.0004645699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009510032,"about_ca_system_score_gemma":0.00041645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002074802,"about_ca_topic_score_gemma":0.002880644,"domain_scores_codex":[0.9994099,0.0002425935,0.00005354855,0.0001307248,0.00009636708,0.00006695854],"domain_scores_gemma":[0.9990233,0.0001234606,0.0003141955,0.00004141971,0.0001032825,0.0003944041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2335155,0.002429739,0.6991963,0.0005604968,0.007671344,0.0004192511,0.0002230114,0.001505216,0.006703053,0.0001501365,0.005678524,0.04194726],"study_design_scores_gemma":[0.03400448,0.04284011,0.9107803,0.0001361711,0.003392426,0.0004157464,0.0001219351,0.001040406,0.0009270363,0.0001029059,0.006201103,0.00003745188],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912949,0.004829722,0.0001241672,0.0003171175,0.00005467208,0.0001267885,0.001864569,0.00001594267,0.001372106],"genre_scores_gemma":[0.9934201,0.0007781634,0.00009030823,0.0003219727,0.00009405977,0.0001224366,0.004361229,0.000004808069,0.0008069232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002074802,"threshold_uncertainty_score":0.00744468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008855952597589074,"score_gpt":0.2450804213932807,"score_spread":0.2362244687956916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}