{"id":"W3212580903","doi":"10.1016/j.isci.2021.103441","title":"Role of extracellular microRNA-146a-5p in host innate immunity and bacterial sepsis","year":2021,"lang":"en","type":"article","venue":"iScience","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; School of Medicine, University of Maryland; National Institute on Aging; National Institutes of Health; International Anesthesia Research Society","keywords":"microRNA; TLR7; Innate immune system; Extracellular; Biology; Cell biology; RNA; Extracellular vesicle; Intracellular; Microvesicles; Immunology; Immune system; Gene; Biochemistry; Toll-like receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000155333,0.0000649006,0.0000780951,0.00002872299,0.00003477949,0.00001841045,0.0001154913,0.00006028241,0.00003224149],"category_scores_gemma":[0.00008145499,0.00006837937,0.00002594085,0.0001440193,0.0001356153,0.000006843939,0.0001539223,0.00003859053,0.000001632545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008532513,"about_ca_system_score_gemma":0.00009161473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003569457,"about_ca_topic_score_gemma":0.00005545287,"domain_scores_codex":[0.9993994,0.00005543143,0.0001370374,0.0002115411,0.00007264663,0.0001238957],"domain_scores_gemma":[0.9996151,0.000006249334,0.00005599864,0.0002292575,0.00005413882,0.00003927911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001916235,0.00003688606,0.003550493,0.00001013174,0.000003244421,0.000002454527,0.00007504205,0.000008572092,0.9951355,0.00002513313,0.00001590267,0.001117405],"study_design_scores_gemma":[0.0001827831,0.00002013342,0.1125784,0.00001379247,0.00000339376,0.000008299646,0.00007507567,0.00006142467,0.8840151,0.00004884082,0.002922542,0.00007016764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949961,0.004594935,0.00006408326,0.00004459861,0.00005059312,0.00005469161,0.00001695327,0.000002272567,0.0001757456],"genre_scores_gemma":[0.9991311,0.0001202172,0.0005774297,0.00001573482,0.00002512461,0.000002524599,0.00002973805,0.000004776491,0.00009333322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1111204,"threshold_uncertainty_score":0.278843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007045880475101707,"score_gpt":0.231868361024006,"score_spread":0.2248224805489043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}