{"id":"W3212592260","doi":"10.1182/blood-2021-152993","title":"Integrated Epigenetic and Transcriptional Single Cell Analysis of t(11;14) Myeloma and Its BCL2 Dependency","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Biology; Cancer research; Gene expression profiling; Multiple myeloma; Epigenomics; Epigenetics; Chromatin; Venetoclax; Epigenetic therapy; Chromosomal translocation; Molecular biology; Gene; Genetics; Gene expression; DNA methylation; Leukemia; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009088617,0.00007455665,0.000185459,0.0001933433,0.0001592353,0.0002264838,0.00008809611,0.0001324552,0.001823371],"category_scores_gemma":[0.00009133909,0.00007747772,0.0001475976,0.0002663333,0.0001231212,0.00007890609,0.0001922541,0.0002368718,0.0002677295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001428857,"about_ca_system_score_gemma":0.000109569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005691873,"about_ca_topic_score_gemma":0.001460624,"domain_scores_codex":[0.9999248,0.000006903671,0.000002765478,0.00003108613,0.00002167927,0.00001282437],"domain_scores_gemma":[0.9999363,0.00001326022,0.00001613832,0.000008956699,0.00001464344,0.00001063539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001470566,0.00001079251,0.006435887,0.00003552641,0.00001291745,0.00003136183,0.00003788366,0.0001050676,0.9900964,0.00002982719,0.00005190017,0.003005394],"study_design_scores_gemma":[0.00001831006,0.0005202672,0.5691341,0.00001526843,0.000087,0.0007919677,0.0003089823,0.002559061,0.4196245,0.000220935,0.006703962,0.00001578473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934741,0.0007718286,0.002366711,0.0000392025,0.00001238423,0.00002201344,0.002517391,0.00004265277,0.0007537497],"genre_scores_gemma":[0.9929863,0.0003460172,0.002196872,0.00005499302,0.000009633271,0.00004368315,0.002754448,0.0000165227,0.001591601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001823371,"threshold_uncertainty_score":0.006099761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02714428134344178,"score_gpt":0.2679746298240504,"score_spread":0.2408303484806086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}