{"id":"W3212602214","doi":"10.1182/blood-2021-153086","title":"A Phase I/II Study of Venetoclax in Combination with 5-Azacytidine in Treatment-Naïve and Relapsed/Refractory High-Risk Myelodysplastic Syndrome (MDS) or Chronic Myelomonocytic Leukemia (CMML)","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chronic myelomonocytic leukemia; Venetoclax; Myelodysplastic syndromes; Azacitidine; Medicine; Refractory (planetary science); Internal medicine; Phases of clinical research; Leukemia; Oncology; Gastroenterology; Chemotherapy; Chronic lymphocytic leukemia; Bone marrow; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001105612,0.0008474761,0.001273362,0.0003616213,0.000392176,0.0007596275,0.0007950284,0.001071702,0.003546232],"category_scores_gemma":[0.0005774227,0.0005001063,0.0008418242,0.0003864405,0.0007634432,0.0005582668,0.0002504319,0.002689071,0.0007192866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000624865,"about_ca_system_score_gemma":0.001379652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008285259,"about_ca_topic_score_gemma":0.002353617,"domain_scores_codex":[0.9996918,0.0001525366,0.00001487488,0.00005892238,0.00002875564,0.00005311105],"domain_scores_gemma":[0.9995936,0.00005679153,0.00006470117,0.0000385346,0.00003094255,0.0002154463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.576883,0.211834,0.007803551,0.001439344,0.001465215,0.0004516387,0.000469979,0.002721998,0.0944085,0.0005187769,0.004523914,0.09748],"study_design_scores_gemma":[0.4289433,0.5556591,0.007346401,0.00004219699,0.0003533094,0.0002732252,0.00006682434,0.0008509325,0.003565546,0.0001448043,0.002732131,0.00002220222],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913982,0.001863532,0.0005370468,0.0002855149,0.0001203073,0.003526415,0.0008185753,0.00007545634,0.001375006],"genre_scores_gemma":[0.9883685,0.001800934,0.001909578,0.0005875503,0.0001295793,0.003285185,0.001485021,0.00002028131,0.002413428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003546232,"threshold_uncertainty_score":0.01186335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01743846894126984,"score_gpt":0.2871701145387691,"score_spread":0.2697316455974993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}