{"id":"W3212610509","doi":"10.1007/s00428-021-03232-0","title":"MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma","year":2021,"lang":"en","type":"article","venue":"Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Health Services; Royal Alexandra Hospital; University of Alberta; Vancouver General Hospital; University of British Columbia; BC Cancer Agency; Foothills Medical Centre; University of Calgary","funders":"Medical Research and Materiel Command; National Institutes of Health; Translational Cancer Research Network; BC Cancer Foundation; University of New South Wales; Michael Smith Health Research BC; Alberta Precision Laboratories; National Health and Medical Research Council; American Cancer Society; Cancer Research UK; University of Calgary; Sydney West Translational Cancer Research Centre; NSW Ministry of Health; Swedish Cancer Foundation; VGH and UBC Hospital Foundation; National Cancer Institute; KWF Kankerbestrijding; National Center for Research Resources; Cancer Institute NSW","keywords":"Immunohistochemistry; Ovarian carcinoma; Chemotherapy; Serous fluid; Cancer research; Serous carcinoma; Internal medicine; Survival analysis; Messenger RNA; Biology; Ovarian cancer; Oncology; Medicine; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006252456,0.0008338917,0.001458985,0.0002030356,0.0003741407,0.00007892945,0.0003040837,0.0004019965,0.0001364277],"category_scores_gemma":[0.0008291006,0.000540529,0.0002877301,0.0006665206,0.0005764834,0.000194211,0.0001722359,0.0007605319,0.00002123762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002294208,"about_ca_system_score_gemma":0.001042246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001489339,"about_ca_topic_score_gemma":0.0001455925,"domain_scores_codex":[0.9952907,0.0003830712,0.0008014729,0.001582801,0.000839962,0.001101982],"domain_scores_gemma":[0.9959649,0.001246614,0.0004955645,0.001143299,0.0007033442,0.0004463005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006084624,0.01146521,0.9579138,0.0003868543,0.004976472,0.001032824,0.001549071,0.0001520756,0.003613673,0.00347487,0.003750459,0.005600135],"study_design_scores_gemma":[0.02563553,0.0059777,0.9570876,0.0005716626,0.002203041,0.00002777438,0.0003523938,0.0005589576,0.004645428,0.0007829896,0.001380179,0.0007767376],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859699,0.0006127818,0.003518437,0.004920035,0.000387252,0.002492431,0.0007731438,0.0002060072,0.001119992],"genre_scores_gemma":[0.9788864,0.0001542404,0.01247111,0.003304633,0.0004159686,0.0005585792,0.003645394,0.0001352852,0.0004284221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0195509,"threshold_uncertainty_score":0.9997046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02961523871704911,"score_gpt":0.3126316593180937,"score_spread":0.2830164206010445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}