{"id":"W3212610509","doi":"10.1007/s00428-021-03232-0","title":"MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma","year":2021,"lang":"en","type":"article","venue":"Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Health Services; Royal Alexandra Hospital; University of Alberta; Vancouver General Hospital; University of British Columbia; BC Cancer Agency; Foothills Medical Centre; University of Calgary","funders":"Medical Research and Materiel Command; National Institutes of Health; Translational Cancer Research Network; BC Cancer Foundation; University of New South Wales; Michael Smith Health Research BC; Alberta Precision Laboratories; National Health and Medical Research Council; American Cancer Society; Cancer Research UK; University of Calgary; Sydney West Translational Cancer Research Centre; NSW Ministry of Health; Swedish Cancer Foundation; VGH and UBC Hospital Foundation; National Cancer Institute; KWF Kankerbestrijding; National Center for Research Resources; Cancer Institute NSW","keywords":"Immunohistochemistry; Ovarian carcinoma; Chemotherapy; Serous fluid; Cancer research; Serous carcinoma; Internal medicine; Survival analysis; Messenger RNA; Biology; Ovarian cancer; Oncology; Medicine; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001733278,0.0002331418,0.0002551679,0.0006609298,0.0003712976,0.0005545758,0.0002578109,0.0003939797,0.002120426],"category_scores_gemma":[0.001146718,0.0001177008,0.0003239833,0.0008858927,0.0002251365,0.0002882528,0.0003347825,0.0004337651,0.0001814088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003602042,"about_ca_system_score_gemma":0.0002902881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00284518,"about_ca_topic_score_gemma":0.004688916,"domain_scores_codex":[0.9998796,0.00001704404,0.00001073423,0.0000202448,0.00003490253,0.00003738708],"domain_scores_gemma":[0.9995321,0.00009291941,0.0002004047,0.0000243162,0.00005649747,0.00009378493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006609289,0.00002694385,0.9852985,0.0000335211,0.00009548709,0.0002092032,0.0000574165,0.0001228949,0.006082979,0.00004485332,0.0002707177,0.007096492],"study_design_scores_gemma":[0.00001457046,0.00009849987,0.9968028,0.000005468211,0.00007063038,0.0004409903,0.0001178245,0.0008232897,0.0009090327,0.00008999548,0.00062029,0.000006533797],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985122,0.0005683399,0.0001086748,0.00007685287,0.00001806964,0.000004386658,0.0003034567,0.000008767038,0.0003992018],"genre_scores_gemma":[0.9992976,0.00008411222,0.00006819284,0.00001755916,0.00001705862,0.000002905115,0.0002659284,0.000001593138,0.0002450462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00284518,"threshold_uncertainty_score":0.007093549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02961523871704911,"score_gpt":0.3126316593180937,"score_spread":0.2830164206010445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}