{"id":"W3212620415","doi":"10.3389/fcell.2021.716604","title":"Microbiome-Mediated Immune Signaling in Inflammatory Bowel Disease and Colorectal Cancer: Support From Meta-omics Data","year":2021,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Public Health Agency of Canada; University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Public Health Agency of Canada","keywords":"Dysbiosis; Microbiome; Metaproteomics; Context (archaeology); Metagenomics; Biology; Immune system; Inflammatory bowel disease; Gut flora; Disease; Immunology; Ulcerative colitis; Human microbiome; Bioinformatics; Medicine; Genetics; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003202282,0.0004855667,0.001407793,0.0002038063,0.0000686858,0.00003249734,0.0003876974,0.0006271569,0.00004590633],"category_scores_gemma":[0.00003539859,0.0004340462,0.000120895,0.0001386554,0.0002210728,0.000008884528,0.0009312645,0.0003318079,0.000003886856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001113186,"about_ca_system_score_gemma":0.0014058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001826531,"about_ca_topic_score_gemma":0.0001836738,"domain_scores_codex":[0.9973744,0.0002437523,0.0007870761,0.00109336,0.0000449157,0.0004564636],"domain_scores_gemma":[0.9992278,0.00004503657,0.0002406261,0.0002898559,0.00002100966,0.0001756392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008105078,0.0007722136,0.1598709,0.01922531,0.008191973,0.0006433833,0.0009345154,0.000002552363,0.4679052,0.000008112702,0.03646785,0.3051675],"study_design_scores_gemma":[0.0009808979,0.00005460809,0.00107989,0.0006055815,0.0007241152,0.00002331352,0.0001976413,0.000004377665,0.001510458,0.00001203119,0.9940155,0.0007915579],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04657115,0.94916,0.00002026329,0.00001953475,0.0005332726,0.0004874635,0.003181087,0.000006547013,0.00002061567],"genre_scores_gemma":[0.0006578965,0.956918,0.003831347,0.0001284594,0.00007126747,0.00008725267,0.0381759,0.00003935558,0.00009050308],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9575477,"threshold_uncertainty_score":0.9998111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02549273462000887,"score_gpt":0.2817485809963642,"score_spread":0.2562558463763553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}