{"id":"W3212628307","doi":"10.1182/blood-2021-147455","title":"DUSP6 Mediates Resistance to JAK2 Inhibition and Drives Myeloproliferative Neoplasm Disease Progression","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Biology; Cancer research; Myeloproliferative neoplasm; Myeloid; Myelofibrosis; Gene expression profiling; Transcriptome; Progenitor cell; Bone marrow; Stem cell; Immunology; Gene expression; Gene; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008768016,0.0001836537,0.0001619378,0.0001597319,0.000140586,0.0002557651,0.0001004613,0.0001451741,0.0009046915],"category_scores_gemma":[0.0001058748,0.00009035877,0.0001495726,0.0001369863,0.0001168053,0.00009998074,0.0001879911,0.0003753933,0.0002354908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000203715,"about_ca_system_score_gemma":0.00009123446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004289982,"about_ca_topic_score_gemma":0.0005814274,"domain_scores_codex":[0.9999055,0.00001048298,0.000005665351,0.00002748253,0.00002647371,0.00002432121],"domain_scores_gemma":[0.9999365,0.000006344097,0.00001953497,0.000006048432,0.00001015195,0.00002140143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001429834,0.00002210778,0.005182372,0.00003877192,0.000009883593,0.00008614628,0.00002632866,0.0002242654,0.9904868,0.0001002879,0.000151957,0.003528083],"study_design_scores_gemma":[0.00002870872,0.0005857998,0.1485036,0.00001919755,0.00003681091,0.001555742,0.0002288773,0.01158604,0.8294607,0.0003614645,0.007620536,0.00001250227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969288,0.0007497414,0.001063964,0.00004388693,0.00001001391,0.000009777837,0.0005929902,0.00006212146,0.0005388455],"genre_scores_gemma":[0.9982795,0.0002395056,0.0003629911,0.00002310949,0.000003615126,0.000009302994,0.000574636,0.000006667115,0.0005008252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009046915,"threshold_uncertainty_score":0.003026426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101228759629547,"score_gpt":0.2705913397530173,"score_spread":0.2604684637900626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}