{"id":"W3212667942","doi":"10.21203/rs.3.rs-1041332/v1","title":"Phase I Pharmacokinetic Study of Single Agent Trametinib in Patients With Advanced Cancer and Hepatic Dysfunction","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Juravinski Cancer Centre; University of Toronto; BC Cancer Agency; Princess Margaret Cancer Centre","funders":"National Cancer Institute; Genentech; Ipsen; Eisai; Bristol-Myers Squibb; Eli Lilly and Company; Symphogen; Exelixis; Iterion Therapeutics; Karyopharm Therapeutics; Celgene; Servier; Amgen","keywords":"Pharmacokinetics; Trametinib; Medicine; Cancer; Oncology; Hepatic dysfunction; Internal medicine; Pharmacology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004980082,0.001139929,0.00173363,0.0002881588,0.0003674489,0.000896127,0.0004633463,0.000873557,0.003290847],"category_scores_gemma":[0.0006440286,0.0005183415,0.001089188,0.0003400327,0.0006372341,0.0008358609,0.0002890624,0.002845464,0.0008798313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001024586,"about_ca_system_score_gemma":0.001496965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001264633,"about_ca_topic_score_gemma":0.001795964,"domain_scores_codex":[0.9998179,0.00005844468,0.000005194854,0.00004374533,0.00001553609,0.00005913958],"domain_scores_gemma":[0.9997056,0.00004200987,0.00005091583,0.00003787418,0.00001866249,0.0001448292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7680227,0.04595283,0.007420041,0.0003453118,0.001385988,0.0003590453,0.0002756864,0.007000402,0.05744692,0.0005236747,0.006478304,0.1047892],"study_design_scores_gemma":[0.4606184,0.4889712,0.02551311,0.00004214173,0.0009013764,0.0008200894,0.0001586486,0.006300269,0.00973018,0.0006443211,0.006208616,0.00009166539],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953378,0.0008492495,0.0006534662,0.000394991,0.00006365982,0.0006188068,0.0009547003,0.00008860081,0.001038751],"genre_scores_gemma":[0.9933509,0.0007872336,0.001057068,0.0003558754,0.00006113847,0.0007710904,0.001454681,0.00004722649,0.002114842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003290847,"threshold_uncertainty_score":0.01100904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0402575144357661,"score_gpt":0.3702354676946973,"score_spread":0.3299779532589313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}