{"id":"W3212675168","doi":"10.1182/blood-2021-144820","title":"Early Integration of High Dose Methotrexate to Frontline DLBCL Therapy Does Not Impact CNS Relapse Compared to End of Treatment Delivery: A Multicentre International Analysis of 1384 Patients","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CNS Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Methotrexate; Internal medicine; Primary central nervous system lymphoma; Oncology; Diffuse large B-cell lymphoma; Proportional hazards model; Lymphoma; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001420808,0.0004372043,0.0008292632,0.0007967447,0.0003887166,0.001188389,0.0006029003,0.0004947227,0.001761604],"category_scores_gemma":[0.003398416,0.0003874806,0.001090076,0.001719199,0.0004978423,0.0004995443,0.0006650597,0.0005447125,0.0003129758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00073507,"about_ca_system_score_gemma":0.0004381245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002111281,"about_ca_topic_score_gemma":0.002114284,"domain_scores_codex":[0.9986169,0.0004520369,0.0001945845,0.000429611,0.0001626303,0.0001441485],"domain_scores_gemma":[0.9963189,0.00075279,0.001869355,0.0003522202,0.0002289343,0.000477707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005092866,0.0001700842,0.9892269,0.00006969743,0.0005459071,0.0002054312,0.0001567369,0.0001100817,0.0007896056,0.00001843566,0.0001510772,0.003463209],"study_design_scores_gemma":[0.0004889671,0.002073032,0.9944013,0.00002393074,0.0005346294,0.001001598,0.0002336643,0.0003678114,0.0002525208,0.00002795501,0.0005804205,0.0000142207],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988762,0.0005239052,0.00009061926,0.00001770722,0.000004824905,0.00001887123,0.0003154244,0.000002448706,0.0001499445],"genre_scores_gemma":[0.9990612,0.0001280499,0.00008891071,0.00003793896,0.00001099623,0.00001843655,0.0005857875,0.000004541987,0.00006414401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002111281,"threshold_uncertainty_score":0.00751406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01998403326403428,"score_gpt":0.3005542960512361,"score_spread":0.2805702627872019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}