{"id":"W3212686797","doi":"10.21203/rs.3.rs-962421/v1","title":"Generation of Genome-Edited Dogs by Somatic Cell Nuclear Transfer","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Welichem Biotech (Canada)","funders":"","keywords":"Somatic cell nuclear transfer; Biology; Genome; CRISPR; Indel; Somatic cell; Genetics; Gene; Genome editing; Bovine genome; Cloning (programming); Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007907531,0.0003304506,0.0003544811,0.0004369462,0.0002200834,0.0005012818,0.0004280448,0.0005701371,0.002360554],"category_scores_gemma":[0.0003663326,0.0002098749,0.0003701902,0.0002101657,0.0003901582,0.0002230637,0.0004361183,0.0006878168,0.0009043877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003267739,"about_ca_system_score_gemma":0.0003232112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003913267,"about_ca_topic_score_gemma":0.000595765,"domain_scores_codex":[0.9995901,0.0000645731,0.00004212347,0.0001268134,0.0001363344,0.00004004146],"domain_scores_gemma":[0.9996922,0.00007663106,0.00007966402,0.00005819735,0.00004647483,0.00004694425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009444212,0.00003547173,0.0004755122,0.0001396969,0.00002616495,0.0003700795,0.00006462887,0.0003343465,0.9919581,0.001409223,0.0004623103,0.004630011],"study_design_scores_gemma":[0.00005157235,0.0002918573,0.002390296,0.00002793781,0.00007395645,0.002278716,0.00004150576,0.002843295,0.9567412,0.0003417277,0.03489766,0.00002032808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7523484,0.003138926,0.2247938,0.000624205,0.000617813,0.0006489059,0.004694436,0.002020586,0.01111297],"genre_scores_gemma":[0.8821868,0.001904446,0.09259404,0.000201138,0.00005643787,0.000270799,0.006489288,0.0005055724,0.01579145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002360554,"threshold_uncertainty_score":0.007896841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03395486649323859,"score_gpt":0.3578986755998799,"score_spread":0.3239438091066413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}