{"id":"W3212689194","doi":"10.1182/blood-2021-150634","title":"Germline-Somatic Interactions in Myelofibrosis Susceptibility","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Biology; Myelofibrosis; Genome-wide association study; Genetics; Loss of heterozygosity; Genotyping; SNP array; Myeloid; Bone marrow; Single-nucleotide polymorphism; Cancer research; Immunology; Genotype; Allele; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002971466,0.0002900289,0.0001690801,0.0008265072,0.0003108117,0.000318897,0.0002104356,0.0003102397,0.003841267],"category_scores_gemma":[0.001316605,0.00009249995,0.0002484979,0.0008851578,0.0001808921,0.0001279557,0.0002863117,0.0002373004,0.000206488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001551634,"about_ca_system_score_gemma":0.000194478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001552012,"about_ca_topic_score_gemma":0.001829274,"domain_scores_codex":[0.9996897,0.00005721352,0.00003010769,0.0001152804,0.00006954819,0.00003813133],"domain_scores_gemma":[0.99949,0.0001405004,0.0002392558,0.00002707166,0.00003935914,0.00006385464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004248606,0.0000601839,0.9656422,0.0000577506,0.0003708153,0.001611386,0.0001297332,0.0004125551,0.01644493,0.0003877963,0.0004128614,0.01404484],"study_design_scores_gemma":[0.00002920293,0.0001354841,0.9898155,0.00002366715,0.0002315914,0.0046068,0.00007161481,0.001083089,0.002383482,0.0004829648,0.001127336,0.000009339847],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979714,0.0004007216,0.0004533179,0.00006625389,0.000006854538,0.000007993363,0.0004862353,0.00001858571,0.0005885459],"genre_scores_gemma":[0.9993683,0.00005301204,0.0002696454,0.00002105924,0.000008591686,0.000002911017,0.0001576638,0.000002729447,0.0001162045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003841267,"threshold_uncertainty_score":0.01285034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02562191376628982,"score_gpt":0.3042765106407568,"score_spread":0.278654596874467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}