{"id":"W3212751896","doi":"10.1016/s1470-2045(21)00536-2","title":"Ceritinib in paediatric patients with anaplastic lymphoma kinase-positive malignancies: an open-label, multicentre, phase 1, dose-escalation and dose-expansion study","year":2021,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"Novartis Pharmaceuticals Corporation","keywords":"Ceritinib; Anaplastic large-cell lymphoma; Lymphoma; Phases of clinical research; Phase (matter)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001649066,0.001239141,0.002948661,0.0002839102,0.0003118398,0.0009757125,0.0006772965,0.0009993303,0.00191281],"category_scores_gemma":[0.001475836,0.0004413501,0.001927889,0.0004407869,0.0009441206,0.001043534,0.0003540426,0.00315251,0.0005055756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001591124,"about_ca_system_score_gemma":0.001956112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001434304,"about_ca_topic_score_gemma":0.003601109,"domain_scores_codex":[0.999306,0.0003312838,0.00003557722,0.0001244204,0.00008157776,0.0001210706],"domain_scores_gemma":[0.998935,0.0002466077,0.0003246553,0.0001016323,0.00006750241,0.0003245476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6819583,0.02222417,0.02979737,0.002834979,0.00624055,0.00118182,0.0007790238,0.009025298,0.02911633,0.000732998,0.009213862,0.2068952],"study_design_scores_gemma":[0.6137454,0.2935447,0.06933601,0.000155716,0.002745826,0.002553135,0.0002302996,0.00252592,0.004315977,0.0004089599,0.01033069,0.000107324],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913896,0.005373464,0.0004654243,0.0003837759,0.00008654378,0.0005599035,0.0007225485,0.00008326612,0.0009355793],"genre_scores_gemma":[0.9914666,0.003929039,0.001285348,0.0005268574,0.00009060663,0.0005686846,0.001363179,0.00004339835,0.0007261943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002948661,"threshold_uncertainty_score":0.01154453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04317782784484444,"score_gpt":0.3491828933605973,"score_spread":0.3060050655157529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}