{"id":"W3212762770","doi":"10.1080/19420862.2021.1982447","title":"Viro-antibody therapy: engineering oncolytic viruses for genetic delivery of diverse antibody-based biotherapeutics","year":2021,"lang":"en","type":"review","venue":"mAbs","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Wilhelm Sander-Stiftung","keywords":"Oncolytic virus; Antibody; Immune system; Virus; Virology; Biology; Bispecific antibody; Immunotherapy; Cancer research; Computational biology; Immunology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003417587,0.00047555,0.0003291966,0.0006009795,0.0001307202,0.0006115463,0.0002958378,0.000507281,0.0004926081],"category_scores_gemma":[0.0001494185,0.0001950788,0.0003103586,0.0003894893,0.0002612857,0.00048467,0.0003185749,0.0007311761,0.0005047729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005314669,"about_ca_system_score_gemma":0.0003444352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003738197,"about_ca_topic_score_gemma":0.0004198672,"domain_scores_codex":[0.9998236,0.00003561766,0.0000114469,0.00003430547,0.000067697,0.00002733376],"domain_scores_gemma":[0.9999638,0.000007623513,0.00001127076,0.000002586108,0.000008090352,0.000006551067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001197828,0.0000966544,0.0004558511,0.001624064,0.00005952445,0.0002519058,0.0001233572,0.001862973,0.8262939,0.02457232,0.002966503,0.1415732],"study_design_scores_gemma":[0.00003481434,0.0004226103,0.0007463332,0.0001684065,0.00008558389,0.001598168,0.00003207655,0.004786628,0.6627997,0.002962609,0.3263218,0.0000413055],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1317035,0.5038114,0.3343279,0.001352565,0.0009525529,0.000473173,0.0007455519,0.001209857,0.0254235],"genre_scores_gemma":[0.5286959,0.2998526,0.1444729,0.001026422,0.0003459451,0.0004613601,0.001332214,0.0002124854,0.02360028],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0006115463,"threshold_uncertainty_score":0.003856063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07056780666259906,"score_gpt":0.392729113254955,"score_spread":0.322161306592356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}