{"id":"W3212762770","doi":"10.1080/19420862.2021.1982447","title":"Viro-antibody therapy: engineering oncolytic viruses for genetic delivery of diverse antibody-based biotherapeutics","year":2021,"lang":"en","type":"review","venue":"mAbs","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Wilhelm Sander-Stiftung","keywords":"Oncolytic virus; Antibody; Immune system; Virus; Virology; Biology; Bispecific antibody; Immunotherapy; Cancer research; Computational biology; Immunology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003085001,0.0005868098,0.001264321,0.0002519203,0.00008297945,0.00004833997,0.0006392907,0.0005665728,0.00008446097],"category_scores_gemma":[0.00005614476,0.0005426633,0.0009853835,0.0003308899,0.0001176173,0.000003532567,0.0001452968,0.0002306982,0.0000144037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006630932,"about_ca_system_score_gemma":0.0009782957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000146995,"about_ca_topic_score_gemma":0.00001319551,"domain_scores_codex":[0.9975984,0.0001914116,0.0006373179,0.0007193899,0.0003221738,0.000531343],"domain_scores_gemma":[0.9982053,0.0001365281,0.0002968989,0.0009878577,0.0002497982,0.000123619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005187615,0.0003198346,0.00003826821,0.007434705,0.001451005,0.00002427849,0.00001739765,0.0003309664,0.3367871,0.000009383703,0.0002073235,0.6528609],"study_design_scores_gemma":[0.001040928,0.002012881,0.000005854345,0.001747085,0.0003313584,0.000009365793,0.000009966317,0.0002004486,0.04877724,0.000001912311,0.9452488,0.0006141634],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01186705,0.9842535,0.001931924,0.00000992906,0.0002385972,0.001253867,0.000408749,0.00002528469,0.00001114737],"genre_scores_gemma":[0.0004715417,0.9956553,0.001730087,0.0001844044,0.0003681651,0.0001447374,0.001135851,0.0002040098,0.0001059095],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9450415,"threshold_uncertainty_score":0.9997025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07056780666259906,"score_gpt":0.392729113254955,"score_spread":0.322161306592356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}