{"id":"W3212774057","doi":"10.1016/j.yjmcc.2021.11.003","title":"Sex- and age-specific regulation of ACE2: Insights into severe COVID-19 susceptibility","year":2021,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Institute of Population and Public Health; Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"TMPRSS2; Angiotensin-converting enzyme 2; Peptidyl-Dipeptidase A; Coronavirus disease 2019 (COVID-19); TMPRSS6; Biology; Serine protease; Sexual dimorphism; Protease; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Disease; Immunology; Virology; Internal medicine; Endocrinology; Medicine; Renin–angiotensin system; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001056186,0.0001279029,0.0008579642,0.0001210345,0.00006846697,0.000009864039,0.00006627655,0.0001687175,0.00003011834],"category_scores_gemma":[0.006416182,0.0001014116,0.0002662652,0.0001574566,0.0004408571,0.00003963558,0.0001748549,0.0003665951,7.410744e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001000814,"about_ca_system_score_gemma":0.0004109021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001119659,"about_ca_topic_score_gemma":0.000005638173,"domain_scores_codex":[0.9980701,0.0005751722,0.000558243,0.000272992,0.0003556116,0.0001678848],"domain_scores_gemma":[0.9977597,0.0009787773,0.0001966337,0.0002925842,0.0004371555,0.0003351756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005998678,0.00008419467,0.02590368,0.000750433,0.0006539276,0.005831362,0.0009715053,0.0004723917,0.959714,0.0003742732,0.0004695843,0.004174799],"study_design_scores_gemma":[0.02300242,0.007190843,0.2487277,0.0005525206,0.001987535,0.003739398,0.004320312,0.0003491054,0.3919424,0.07524085,0.2418782,0.001068752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9578062,0.01663806,0.02244467,0.002639715,0.00009473955,0.0001437942,0.000002027857,0.000005333412,0.0002255129],"genre_scores_gemma":[0.9943193,0.00415865,0.0006912908,0.0005548642,0.0001415647,0.00000136578,0.000008345373,0.000009966788,0.0001146208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5677716,"threshold_uncertainty_score":0.7681233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03459496607983336,"score_gpt":0.3440336888676467,"score_spread":0.3094387227878133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}