{"id":"W3212812892","doi":"10.1182/blood-2021-153724","title":"Integrative Genomic Analysis Uncovers Unique Diffuse Large B Cell Lymphoma (DLBCL) Immune Environments and Identifies Associations with Specific Oncogenic Alterations","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Spinal Cord Injury BC","funders":"","keywords":"Diffuse large B-cell lymphoma; Immune system; Biology; Immune checkpoint; CD8; Cancer research; Lymphoma; Large-cell lymphoma; Chemoimmunotherapy; T cell; Immunology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003473248,0.0002715543,0.0004524987,0.001559156,0.0003384689,0.0005787864,0.0002401144,0.0001925043,0.001426899],"category_scores_gemma":[0.0005762096,0.0001220593,0.0006199057,0.001869732,0.0002623574,0.0001107381,0.0006850378,0.0003246902,0.0002725872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003162737,"about_ca_system_score_gemma":0.0004610938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003172547,"about_ca_topic_score_gemma":0.006792875,"domain_scores_codex":[0.9996456,0.00003592513,0.00001768011,0.0001835481,0.00005905287,0.000058136],"domain_scores_gemma":[0.9997051,0.0000968284,0.00008867012,0.00003027787,0.00003233669,0.00004677674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00111325,0.0001309095,0.6643091,0.000679602,0.001363106,0.0008355955,0.0004285836,0.003697741,0.2511074,0.0007498377,0.002330345,0.07325453],"study_design_scores_gemma":[0.00003886883,0.0002047948,0.9788079,0.00004396648,0.0005793602,0.0009837117,0.0002675244,0.004872424,0.007441415,0.0007088688,0.006029319,0.00002175268],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849999,0.001417717,0.003225105,0.00009038278,0.000009974391,0.0000236688,0.009185091,0.0001373518,0.000910687],"genre_scores_gemma":[0.9838684,0.000450971,0.003146813,0.00009786073,0.00001084617,0.00003556476,0.0119226,0.00004412081,0.0004228386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003172547,"threshold_uncertainty_score":0.006308138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006890774325263639,"score_gpt":0.2171283200614501,"score_spread":0.2102375457361864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}