{"id":"W3212818441","doi":"10.1101/2021.10.31.466683","title":"Reproducible Discovery of Cell-Binding Peptides “Lost” in Bulk Amplification via Emulsion Amplification in Phage Display Panning","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Glycomics Centre","keywords":"Panning (audio); Phage display; Population; Biology; Context (archaeology); Peptide library; Phagemid; Genomic library; Cell; Molecular biology; Computational biology; Bacteriophage; Gene; Genetics; Peptide; Biochemistry; Peptide sequence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007121477,0.0003690077,0.0003081661,0.0002411045,0.0001318282,0.0006426583,0.0002988347,0.0004284234,0.001366953],"category_scores_gemma":[0.0006253789,0.0002448645,0.0002179729,0.0002015846,0.0003903613,0.0003309431,0.0005743043,0.0007371198,0.0006888276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002984073,"about_ca_system_score_gemma":0.0001814761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001945907,"about_ca_topic_score_gemma":0.0003171611,"domain_scores_codex":[0.9996132,0.00005863356,0.00001702537,0.0001036445,0.0001438352,0.00006362707],"domain_scores_gemma":[0.999723,0.0001215479,0.00003506694,0.00003469464,0.00005076098,0.00003493799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002202567,0.000008568411,0.00004051221,0.00001481889,0.000001822409,0.00001615867,0.00001147462,0.00008113567,0.99858,0.0001037514,0.00003309167,0.001086624],"study_design_scores_gemma":[0.000006259831,0.00005297297,0.0001818143,0.0000024139,0.000002759617,0.00003315985,0.000005426558,0.00136748,0.9975656,0.00005571824,0.0007233111,0.000003049428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8729892,0.0009741241,0.1206113,0.000187077,0.0000779768,0.0002263683,0.0002990581,0.0007529961,0.00388182],"genre_scores_gemma":[0.93331,0.0007556072,0.05809893,0.0002089407,0.0000209676,0.0002221437,0.0004730654,0.0002620517,0.006648453],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001366953,"threshold_uncertainty_score":0.004572868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02610365890278361,"score_gpt":0.2792614159530086,"score_spread":0.253157757050225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}