{"id":"W3212852675","doi":"10.1177/20543581211057708","title":"A Canadian Study of Cisplatin Metabolomics and Nephrotoxicity (ACCENT): A Clinical Research Protocol","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Kidney Health and Disease","topic":"Chemotherapy-induced organ toxicity mitigation","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Western Ontario; University of Alberta; Princess Margaret Cancer Centre; University of Manitoba; University Health Network; CancerCare Manitoba; Ontario Institute for Cancer Research; Institute for Clinical Evaluative Sciences; McGill University Health Centre; University of Toronto; Montreal Children's Hospital; Western University; BC Children's Hospital; SickKids Foundation; University of British Columbia; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Nephrotoxicity; Cisplatin; Kidney disease; Creatinine; Acute kidney injury; Internal medicine; Nephrology; Metabolomics; Biomarker; Cohort; Urinary system; Intensive care medicine; Oncology; Kidney; Chemotherapy; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.001651793,0.0001234641,0.0004946457,0.0004867457,0.0002473503,0.00004706436,0.00008393559,0.00008791614,0.0001245979],"category_scores_gemma":[0.02440109,0.000116542,0.00006993642,0.0004117503,0.0001589865,0.00009819679,0.00001527328,0.0005938964,0.000001025091],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004170259,"about_ca_system_score_gemma":0.1698197,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.1271446,"about_ca_topic_score_gemma":0.3417145,"domain_scores_codex":[0.9976249,0.0005032644,0.0008296306,0.0002370522,0.0003319071,0.0004732712],"domain_scores_gemma":[0.9451932,0.0001106407,0.0002658496,0.0002568189,0.000673531,0.05349997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009196581,0.0005125427,0.9071587,0.0008307827,0.0001251101,0.001194318,0.002509965,5.310746e-7,0.0002433193,0.0001028997,0.07657202,0.009830172],"study_design_scores_gemma":[0.03857316,0.007768851,0.7551655,0.002217476,0.0003484452,0.0008858203,0.01256346,0.0002973882,0.001399106,0.001572513,0.1786065,0.0006018938],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9273447,0.0004077326,0.000004424599,0.05770066,0.00007216772,0.01427964,0.00009945912,0.000002681404,0.00008854645],"genre_scores_gemma":[0.9636507,0.0000732881,0.0003990606,0.03499713,0.0002795869,0.0004760211,0.00001403022,0.00002791286,0.00008223906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.21457,"threshold_uncertainty_score":0.9838168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09782134275379942,"score_gpt":0.4444070897085309,"score_spread":0.3465857469547314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}