{"id":"W3212884449","doi":"10.1016/s2152-2650(21)02100-5","title":"OAB-026: MagnetisMM-1 study of elranatamab (PF-06863135), a B-cell maturation antigen (BCMA) targeted CD3-engaging bispecific molecule, for patients (pts) with relapsed or refractory multiple myeloma (MM)","year":2021,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Institute of Cancer Research; McGill University Health Centre; Alberta Cancer Foundation; University of Calgary","funders":"","keywords":"Medicine; Cytokine release syndrome; Common Terminology Criteria for Adverse Events; Adverse effect; Internal medicine; Minimal residual disease; Pharmacokinetics; Multiple myeloma; Oncology; Gastroenterology; Pharmacodynamics; Neutropenia; Pharmacology; Toxicity; Chimeric antigen receptor; Bone marrow; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011086,0.001114435,0.001509273,0.0003887852,0.0003958113,0.0009723586,0.0008017615,0.001280588,0.005115549],"category_scores_gemma":[0.0005231472,0.0005337811,0.001169999,0.0002952987,0.0008340068,0.0008185975,0.0003901441,0.003423329,0.001271779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001080984,"about_ca_system_score_gemma":0.001438451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001276855,"about_ca_topic_score_gemma":0.002606044,"domain_scores_codex":[0.9996684,0.0001167329,0.00001513052,0.00005370705,0.00003162174,0.0001144867],"domain_scores_gemma":[0.9997117,0.00002839732,0.00003602969,0.00002170014,0.00001362638,0.0001885588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7449498,0.05674355,0.004152718,0.0006981672,0.001508339,0.0002809446,0.0002699016,0.002017488,0.0576203,0.0007970629,0.004967278,0.1259944],"study_design_scores_gemma":[0.3894156,0.581217,0.009422774,0.00004429557,0.0009302982,0.0003579962,0.00007011609,0.001256731,0.00844474,0.0002737671,0.008521304,0.00004547472],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894813,0.003079555,0.0005165978,0.0009353998,0.00029101,0.001155501,0.0009866746,0.0001186965,0.003435386],"genre_scores_gemma":[0.9893162,0.001459634,0.0008637501,0.001187977,0.000240263,0.0009725482,0.001330632,0.00002941351,0.004599637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005115549,"threshold_uncertainty_score":0.01711321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03815605887531519,"score_gpt":0.3225407780146792,"score_spread":0.284384719139364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}