{"id":"W3212886181","doi":"10.1093/brain/awab419","title":"The neuroradiology of progressive multifocal leukoencephalopathy: a clinical trial perspective","year":2021,"lang":"en","type":"review","venue":"Brain","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"NeuroRx Research (Canada)","funders":"National Institutes of Health","keywords":"Progressive multifocal leukoencephalopathy; Neuroradiology; JC virus; Medicine; Clinical trial; Histopathology; Pathology; Neurology; Slow virus; Leukoencephalopathy; White matter; Magnetic resonance imaging; Radiology; Virus; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005897614,0.0003017623,0.002261118,0.00007662978,0.00009734747,0.00001644121,0.0002339002,0.000561407,0.00004112295],"category_scores_gemma":[0.006321582,0.000157294,0.001554594,0.00027909,0.0007214258,0.00001657955,0.0001130236,0.0008830483,0.00002952661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007960077,"about_ca_system_score_gemma":0.00248891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001453113,"about_ca_topic_score_gemma":0.00000195146,"domain_scores_codex":[0.9966043,0.001256155,0.001067906,0.0005237681,0.0002419541,0.0003059303],"domain_scores_gemma":[0.9957741,0.002627993,0.0006446048,0.000555213,0.0001894031,0.0002086127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002302013,0.0005542499,0.000008564548,0.0009801434,0.0008429266,0.0008389834,0.00006947628,4.74503e-8,2.0959e-7,0.001606966,0.006032982,0.9867634],"study_design_scores_gemma":[0.0107256,0.001180724,0.00003025513,0.005316664,0.002008609,0.0004139667,0.0001530066,0.000006812294,1.950691e-7,0.00003839402,0.9799691,0.0001566378],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001075473,0.9955704,0.000003218753,0.0005352567,0.001022822,0.001873006,0.00005497405,0.00003070147,0.0008021017],"genre_scores_gemma":[0.0000647089,0.9974573,0.00003555047,0.000160811,0.001235859,0.0001658025,0.00006488332,0.00004223865,0.000772887],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9866068,"threshold_uncertainty_score":0.756798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1584084981362457,"score_gpt":0.5138018632575905,"score_spread":0.3553933651213448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}