{"id":"W3212903297","doi":"10.3389/fmicb.2021.778950","title":"NLRP3 Inflammasome Activation Enhanced by TRIM25 is Targeted by the NS1 Protein of 2009 Pandemic Influenza A Virus","year":2021,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Innovation Saskatchewan","keywords":"Inflammasome; Influenza A virus; Biology; Signal transducing adaptor protein; Cell biology; Innate immune system; Ubiquitin ligase; Pyrin domain; Virus; Virology; Phosphorylation; Ubiquitin; Immunology; Genetics; Inflammation; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003523547,0.0002909739,0.0006049012,0.0001712079,0.0001188772,0.00001117068,0.000426984,0.0006762443,0.0006668374],"category_scores_gemma":[0.0002815013,0.0002323425,0.0001435471,0.0003414736,0.0005205956,0.0001021399,0.0001359669,0.0006425342,0.000093942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000125142,"about_ca_system_score_gemma":0.0002012314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001348743,"about_ca_topic_score_gemma":0.00001919764,"domain_scores_codex":[0.9973106,0.0009650274,0.0006992668,0.0004514036,0.00002482368,0.0005488108],"domain_scores_gemma":[0.9989448,0.0001356521,0.0003211172,0.0004458673,0.0001357223,0.00001688101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001088541,0.0001241004,0.0009560922,0.00001577346,0.0001998229,8.554155e-7,0.0006397766,9.043161e-7,0.8229374,0.00001200573,0.1716464,0.002378291],"study_design_scores_gemma":[0.001795283,0.0001736542,0.0002919611,0.00004996167,0.00001701434,0.00002095904,0.0004733309,8.716536e-7,0.77659,0.00006671162,0.2203295,0.0001906751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746319,0.02136445,0.001658246,0.0004046754,0.0008129745,0.0005201181,0.0003989734,0.00004091322,0.0001677601],"genre_scores_gemma":[0.9853666,0.0004754044,0.0002547923,0.001765411,0.000018974,0.0001069762,0.0007608692,0.00003244355,0.01121857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0486831,"threshold_uncertainty_score":0.9474652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007494357869598864,"score_gpt":0.2311935360499159,"score_spread":0.223699178180317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}