{"id":"W3212910239","doi":"10.1016/j.htct.2021.10.1047","title":"INTEGRATED EFFICACY RESULTS FROM THE PHASE 2 AND PHASE 3 STUDIES WITH CAPLACIZUMAB IN PATIENTS WITH ACQUIRED THROMBOTIC THROMBOCYTOPENIC PURPURA","year":2021,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Medicine; Internal medicine; Gastroenterology; Hazard ratio; Exacerbation; Placebo; Platelet; Refractory (planetary science); Randomized controlled trial; Surgery; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01464741,0.000881917,0.002590131,0.0007322406,0.0002773252,0.001639769,0.0006816133,0.001085047,0.001915235],"category_scores_gemma":[0.007591558,0.0004854313,0.004734654,0.0009916438,0.0004340295,0.0008108609,0.0006143431,0.002134228,0.0002286719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009016915,"about_ca_system_score_gemma":0.001991305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005660178,"about_ca_topic_score_gemma":0.002194825,"domain_scores_codex":[0.9934945,0.004121111,0.0004603045,0.0004717043,0.0009969604,0.0004553819],"domain_scores_gemma":[0.9923267,0.003136043,0.002234288,0.0004563065,0.001078388,0.000768173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.6726511,0.006139934,0.04179863,0.005199671,0.04874255,0.0002230995,0.0002872552,0.004476134,0.01420289,0.0005188619,0.003948846,0.201811],"study_design_scores_gemma":[0.470846,0.23853,0.211719,0.0009045108,0.05362217,0.0006379816,0.0001617102,0.003616239,0.00576165,0.0008223175,0.01324954,0.0001288482],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9406954,0.04104629,0.002884464,0.001104716,0.0002264207,0.003606003,0.005820463,0.0001004019,0.004515899],"genre_scores_gemma":[0.9840497,0.004972149,0.002351088,0.0008609443,0.0003073233,0.001943338,0.004897022,0.00002263756,0.0005957005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01464741,"threshold_uncertainty_score":0.07746381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02822739829833527,"score_gpt":0.2841239280980491,"score_spread":0.2558965297997139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}