{"id":"W3212910239","doi":"10.1016/j.htct.2021.10.1047","title":"INTEGRATED EFFICACY RESULTS FROM THE PHASE 2 AND PHASE 3 STUDIES WITH CAPLACIZUMAB IN PATIENTS WITH ACQUIRED THROMBOTIC THROMBOCYTOPENIC PURPURA","year":2021,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Medicine; Internal medicine; Gastroenterology; Hazard ratio; Exacerbation; Placebo; Platelet; Refractory (planetary science); Randomized controlled trial; Surgery; Confidence interval; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001369179,0.0003058226,0.0006759379,0.00005576097,0.0002773794,0.00002495862,0.0001415268,0.0001311817,0.000405444],"category_scores_gemma":[0.00002495811,0.0001681147,0.00004077877,0.0002099556,0.0005035393,0.00007912825,0.00003773885,0.0001805485,0.00001031679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002069901,"about_ca_system_score_gemma":0.00008403518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001098888,"about_ca_topic_score_gemma":0.0005779963,"domain_scores_codex":[0.9980894,0.0005316486,0.0004256196,0.0005785339,0.00006534157,0.0003094789],"domain_scores_gemma":[0.9987041,0.000640981,0.0001183334,0.0003852926,0.0001162377,0.00003509659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1918008,0.04190747,0.2383939,0.0003731925,0.008250222,0.000899214,0.08194142,0.00001369722,0.3306758,0.00135508,0.007355001,0.09703419],"study_design_scores_gemma":[0.6051296,0.00739233,0.1694331,0.001143283,0.0006367998,0.0003357804,0.0259235,0.00002053522,0.1790206,0.0003017829,0.009281602,0.001381035],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791753,0.01886298,0.00002978223,0.0006351072,0.0001367324,0.0008394808,0.0002138306,0.00004478894,0.0000620414],"genre_scores_gemma":[0.9954773,0.003473629,0.00004161895,0.0002640058,0.000006024768,0.00004776411,0.0005981037,0.0000211014,0.00007048045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4133287,"threshold_uncertainty_score":0.6855518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02822739829833527,"score_gpt":0.2841239280980491,"score_spread":0.2558965297997139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}