{"id":"W3212910936","doi":"10.1182/blood-2021-152149","title":"Mapping the Multiple Myeloma T Cell Landscape By Immunotherapeutic Perturbation Reveals Mechanism and Determinants of Response to Bispecific T Cell Engagers","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Immune system; Chimeric antigen receptor; Bone marrow; Immunotherapy; T cell; Medicine; Multiple myeloma; Antigen; Cancer research; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001080268,0.0001235764,0.0002000253,0.0001816481,0.0001272274,0.0002660747,0.00008789496,0.0001763776,0.00107953],"category_scores_gemma":[0.0001145645,0.00008947305,0.0001376938,0.000178668,0.0001336742,0.00009303515,0.0001572946,0.0003071841,0.0002325407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001226604,"about_ca_system_score_gemma":0.00007206339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004478295,"about_ca_topic_score_gemma":0.0004988874,"domain_scores_codex":[0.9998815,0.0000171099,0.000006296926,0.00004183856,0.00002510258,0.00002806595],"domain_scores_gemma":[0.9999501,0.00001095742,0.00001145311,0.000007631134,0.000009972713,0.000009882731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001199704,0.00001041821,0.002298496,0.00001017251,0.000005354925,0.00001083827,0.00002497469,0.0001123351,0.9958044,0.00001807277,0.0000135585,0.001571414],"study_design_scores_gemma":[0.00001927573,0.000901717,0.1641784,0.000006678194,0.0000437139,0.0003698438,0.0002362921,0.00458145,0.8277361,0.0001461727,0.001773046,0.000007338198],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974197,0.00025802,0.001602645,0.00002074898,0.000003711355,0.00001039824,0.0002901315,0.00002239534,0.0003722371],"genre_scores_gemma":[0.9981266,0.0001115544,0.0008784484,0.00003043759,0.000003165052,0.00001942696,0.0003398405,0.000007374691,0.0004830672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00107953,"threshold_uncertainty_score":0.003611386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02881388993851422,"score_gpt":0.2679662286620868,"score_spread":0.2391523387235726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}