{"id":"W3212994588","doi":"10.1016/j.htct.2021.09.002","title":"Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. II: CAR-T cell therapy for patients with CD19+ acute lymphoblastic leukemia","year":2021,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Chimeric antigen receptor; Cytokine release syndrome; Medicine; CD19; Hematology; Lymphoblastic Leukemia; CAR T-cell therapy; Cell therapy; Oncology; Leukemia; T cell; Internal medicine; Immunology; Disease; Acute lymphocytic leukemia; Cancer research; Antigen; Cell; Immune system; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00375961,0.0004175092,0.0006957382,0.003408515,0.0006573732,0.001187963,0.0006974204,0.001339307,0.007975365],"category_scores_gemma":[0.006577478,0.0002384824,0.0006192824,0.005028576,0.0008840507,0.0004550306,0.0008593628,0.001661719,0.002390702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001717686,"about_ca_system_score_gemma":0.004109475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008606462,"about_ca_topic_score_gemma":0.01041817,"domain_scores_codex":[0.9977424,0.000483139,0.0004448224,0.0003444189,0.0007632222,0.0002220066],"domain_scores_gemma":[0.9945582,0.0008781113,0.001396235,0.0003726537,0.002117869,0.0006769647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008097919,0.0002181789,0.06646766,0.004675743,0.0002508769,0.001112362,0.0004397397,0.000667616,0.01827436,0.0195224,0.1793831,0.7081782],"study_design_scores_gemma":[0.00008852516,0.0001720622,0.06295064,0.002702386,0.0002879266,0.00400446,0.0002338372,0.0004111273,0.004043538,0.002183927,0.9228781,0.00004347974],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"methods","genre_scores_codex":[0.07675505,0.5481225,0.01949727,0.1441085,0.02976998,0.00105442,0.008426228,0.0006291665,0.1716368],"genre_scores_gemma":[0.4524049,0.4226773,0.02900566,0.02011396,0.01462269,0.001082427,0.007676329,0.0003840262,0.05203271],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.008606462,"threshold_uncertainty_score":0.02668029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0158641455736322,"score_gpt":0.2614555756327584,"score_spread":0.2455914300591262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}