{"id":"W3212994588","doi":"10.1016/j.htct.2021.09.002","title":"Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. II: CAR-T cell therapy for patients with CD19+ acute lymphoblastic leukemia","year":2021,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Chimeric antigen receptor; Cytokine release syndrome; Medicine; CD19; Hematology; Lymphoblastic Leukemia; CAR T-cell therapy; Cell therapy; Oncology; Leukemia; T cell; Internal medicine; Immunology; Disease; Acute lymphocytic leukemia; Cancer research; Antigen; Cell; Immune system; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003107525,0.0007706468,0.001398634,0.0002561412,0.0005506749,0.00007379937,0.0002684619,0.0007605376,0.001271904],"category_scores_gemma":[0.00001914241,0.000614016,0.0004196119,0.0003868087,0.0004206938,0.00004495854,0.00004604635,0.0006441396,0.00001579321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002407547,"about_ca_system_score_gemma":0.000829947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003256876,"about_ca_topic_score_gemma":0.00001556671,"domain_scores_codex":[0.9957252,0.0003964272,0.0007211171,0.001258873,0.0006845953,0.001213841],"domain_scores_gemma":[0.9971703,0.0007508282,0.0001854521,0.0008236217,0.0005096373,0.0005601586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01924326,0.003892232,0.02254311,0.0003666892,0.0008099392,0.0007225446,0.002233905,0.00002915875,0.9362845,0.0002621513,0.001177312,0.01243517],"study_design_scores_gemma":[0.0453858,0.007465551,0.006192011,0.0001547852,0.0002014022,0.0004981991,0.0002389949,0.0008623116,0.9336301,0.0002444081,0.00430077,0.0008256428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914517,0.002165834,0.001416921,0.000713107,0.0002416298,0.002365864,0.0001063804,0.0001616378,0.001376952],"genre_scores_gemma":[0.9800261,0.009523473,0.002962177,0.003444003,0.0000760736,0.0002373469,0.0002082726,0.0001956839,0.003326856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02614253,"threshold_uncertainty_score":0.9996411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0158641455736322,"score_gpt":0.2614555756327584,"score_spread":0.2455914300591262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}