{"id":"W3213024712","doi":"10.1182/blood-2021-149312","title":"CXCR4 Drives Lympho-Myeloid Fate of Hematopoietic Progenitors <i>Via</i> mTOR and Mitochondrial Metabolic Pathways","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Biology; Myeloid; Haematopoiesis; Progenitor cell; Cell biology; Stem cell; Bone marrow; PI3K/AKT/mTOR pathway; Immunology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001537608,0.0001502189,0.0001321972,0.0001770005,0.0001676368,0.0004139561,0.0002195951,0.0002762314,0.003139481],"category_scores_gemma":[0.00006838549,0.0001282322,0.0001909074,0.0001228818,0.0002252271,0.0001912139,0.0002689184,0.0008658473,0.0006626472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004442967,"about_ca_system_score_gemma":0.0003670641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001024381,"about_ca_topic_score_gemma":0.001806047,"domain_scores_codex":[0.999713,0.00004602563,0.00002355261,0.00005653179,0.00006063784,0.0001002084],"domain_scores_gemma":[0.9998981,0.00001017352,0.00003582806,0.000008073465,0.000009095942,0.00003868875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001503239,0.00004611336,0.0005746302,0.00005182416,0.000003886197,0.00004125522,0.00002634812,0.00008667358,0.9959881,0.0008127203,0.0002566061,0.001961457],"study_design_scores_gemma":[0.00004968403,0.0004281497,0.0143666,0.00002825295,0.00001978015,0.0002892818,0.0001538773,0.002385254,0.9716944,0.000182949,0.01039065,0.00001115503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987518,0.001602057,0.002143974,0.0002962453,0.0000444718,0.00003550575,0.001052138,0.000130699,0.007176888],"genre_scores_gemma":[0.9918056,0.000541185,0.001160263,0.0001599303,0.000008740069,0.00004142535,0.000749652,0.00003248711,0.00550075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003139481,"threshold_uncertainty_score":0.01050258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01355642959346022,"score_gpt":0.2489790720100907,"score_spread":0.2354226424166305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}