{"id":"W3213060608","doi":"10.1212/wnl.0000000000012868","title":"Dopaminergic Therapy for Motor Symptoms in Early Parkinson Disease Practice Guideline Summary","year":2021,"lang":"en","type":"article","venue":"Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; Alberta Children's Hospital Research Institute; Parkinsonfonden; National Institutes of Health; Amneal Pharmaceuticals; Merz Pharmaceuticals; Mitsubishi Tanabe Pharma Corporation; Davis Phinney Foundation; Acorda Therapeutics; University of Cambridge; Fondation Desmarest; Eli Lilly and Company; Adamas Pharmaceuticals; Supernus Pharmaceuticals; Civitas Therapeutics; Allergan; Rush University; F. Hoffmann-La Roche; Sarepta Therapeutics; Agency for Healthcare Research and Quality; Northwestern University; Neurocrine Biosciences; ACADIA Pharmaceuticals; Kaiser Permanente; US WorldMeds; Michael J. Fox Foundation for Parkinson's Research; Jazz Pharmaceuticals; Parkinson's Foundation; Britannia Pharmaceuticals; Weston Brain Institute; Ipsen; UCB US; Dystonia Medical Research Foundation; H. Lundbeck A/S; Sunovion; EVER Neuro Pharma; Amadys; Sanofi; Revance; Boston Scientific Corporation; Biogen; Agence Nationale de la Recherche; Demensförbundet; Florida Department of Health; National Parkinson Foundation; Teva Pharmaceutical Industries; Cleveland Clinic; AstraZeneca; International Parkinson and Movement Disorder Society; Pfizer; Axial Biotherapeutics; Patient-Centered Outcomes Research Institute; Sun Pharma; European Academy of Neurology; American Brain Foundation; Denali Therapeutics","keywords":"Levodopa; Entacapone; Dopamine; Guideline; Dopaminergic; Dopamine agonist; Disease; Ropinirole","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001360331,0.0001991942,0.0003238081,0.0001119083,0.00004649525,0.00001486623,0.00007684308,0.0001074393,0.0000839826],"category_scores_gemma":[0.000341883,0.0001768554,0.0001422451,0.0001715346,0.00003168613,0.00009573425,0.00003901999,0.0001603322,0.00002576236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002891688,"about_ca_system_score_gemma":0.0002299153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007319161,"about_ca_topic_score_gemma":0.00001868277,"domain_scores_codex":[0.9984261,0.0001587107,0.0003167079,0.0005522582,0.0001813484,0.000364849],"domain_scores_gemma":[0.9988145,0.0002366246,0.00009378563,0.000405285,0.0001718886,0.0002779746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1351783,0.01673922,0.6309403,0.0002766783,0.001360487,0.06108384,0.0003188509,0.0001344147,0.02769045,0.004726695,0.01793689,0.1036138],"study_design_scores_gemma":[0.008002711,0.002282091,0.2545596,0.0000138979,0.0001682312,0.0001067608,0.000004353134,0.0007512989,0.0004446261,0.0005926837,0.732936,0.0001377391],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798803,0.004242891,0.000181867,0.01379615,0.0004029969,0.0007133368,0.00008680428,0.0000645434,0.00063108],"genre_scores_gemma":[0.9708015,0.00106333,0.001235037,0.02547799,0.0002715898,0.0003189507,0.0002396134,0.00005122072,0.0005407801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7149991,"threshold_uncertainty_score":0.7211955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01611860122680669,"score_gpt":0.2927308217299716,"score_spread":0.2766122205031649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}