{"id":"W3213060608","doi":"10.1212/wnl.0000000000012868","title":"Dopaminergic Therapy for Motor Symptoms in Early Parkinson Disease Practice Guideline Summary","year":2021,"lang":"en","type":"article","venue":"Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; Alberta Children's Hospital Research Institute; Parkinsonfonden; National Institutes of Health; Amneal Pharmaceuticals; Merz Pharmaceuticals; Mitsubishi Tanabe Pharma Corporation; Davis Phinney Foundation; Acorda Therapeutics; University of Cambridge; Fondation Desmarest; Eli Lilly and Company; Adamas Pharmaceuticals; Supernus Pharmaceuticals; Civitas Therapeutics; Allergan; Rush University; F. Hoffmann-La Roche; Sarepta Therapeutics; Agency for Healthcare Research and Quality; Northwestern University; Neurocrine Biosciences; ACADIA Pharmaceuticals; Kaiser Permanente; US WorldMeds; Michael J. Fox Foundation for Parkinson's Research; Jazz Pharmaceuticals; Parkinson's Foundation; Britannia Pharmaceuticals; Weston Brain Institute; Ipsen; UCB US; Dystonia Medical Research Foundation; H. Lundbeck A/S; Sunovion; EVER Neuro Pharma; Amadys; Sanofi; Revance; Boston Scientific Corporation; Biogen; Agence Nationale de la Recherche; Demensförbundet; Florida Department of Health; National Parkinson Foundation; Teva Pharmaceutical Industries; Cleveland Clinic; AstraZeneca; International Parkinson and Movement Disorder Society; Pfizer; Axial Biotherapeutics; Patient-Centered Outcomes Research Institute; Sun Pharma; European Academy of Neurology; American Brain Foundation; Denali Therapeutics","keywords":"Levodopa; Entacapone; Dopamine; Guideline; Dopaminergic; Dopamine agonist; Disease; Ropinirole","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007608976,0.001419302,0.002658043,0.004009055,0.0007351093,0.002016319,0.004210311,0.00406835,0.007116214],"category_scores_gemma":[0.027663,0.0007300423,0.004180862,0.004412987,0.0005982014,0.001808526,0.001354222,0.003305605,0.00352235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004284309,"about_ca_system_score_gemma":0.01486257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01462663,"about_ca_topic_score_gemma":0.04448608,"domain_scores_codex":[0.9919777,0.003082194,0.002729778,0.0003391164,0.001575848,0.0002953696],"domain_scores_gemma":[0.9830118,0.006087004,0.003544043,0.0002559542,0.006539577,0.0005616471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002192708,0.0001400459,0.001634973,0.1839396,0.001559235,0.0006005754,0.0004798641,0.001482865,0.0006279467,0.003920741,0.4567468,0.3486481],"study_design_scores_gemma":[0.0009102291,0.0002603966,0.005536462,0.4606743,0.004032078,0.001099438,0.0002152205,0.0008327304,0.0003947971,0.004139813,0.5218164,0.0000881182],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004622426,0.7495844,0.01440363,0.1199107,0.009743724,0.01404465,0.01759786,0.0005937687,0.06949873],"genre_scores_gemma":[0.02897831,0.7460914,0.1078904,0.05487723,0.003609999,0.01451576,0.02632533,0.0001413849,0.01757019],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01462663,"threshold_uncertainty_score":0.04024059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01611860122680669,"score_gpt":0.2927308217299716,"score_spread":0.2766122205031649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}