{"id":"W3213060923","doi":"10.1016/j.bioorg.2021.105456","title":"Synthesis, characterization and biological evaluation of thiadiazole amide derivatives as nucleoside triphosphate diphosphohydrolases (NTPDases) inhibitors","year":2021,"lang":"en","type":"article","venue":"Bioorganic Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Crohn's and Colitis Canada; Deutscher Akademischer Austauschdienst","keywords":"Chemistry; Nucleotide; Nucleoside; Nucleoside triphosphate; Enzyme; Isozyme; Extracellular; Biochemistry; Stereochemistry; Amide; Dephosphorylation; Phosphatase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002397346,0.0001753163,0.0001952941,0.00001386192,0.0000682611,0.00002312581,0.00009792516,0.0002118012,0.0003906219],"category_scores_gemma":[0.0008703201,0.0001688056,0.00006803568,0.0001478574,0.0001038746,0.000008670672,0.0001230425,0.00006832767,0.000003804129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001952131,"about_ca_system_score_gemma":0.0001998703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001273283,"about_ca_topic_score_gemma":6.166182e-7,"domain_scores_codex":[0.9988786,0.00007323999,0.0002877558,0.000391726,0.0002015451,0.0001671169],"domain_scores_gemma":[0.9992463,0.00003971174,0.0001714467,0.000244166,0.0002180004,0.00008034725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003404009,0.00007439534,0.004896502,0.00003788402,0.00005699637,0.000004253333,0.00003500484,0.000004728189,0.9929233,0.000006792593,0.0002617952,0.001664288],"study_design_scores_gemma":[0.0004345203,0.00003482876,0.005905174,0.000052766,0.00006858251,0.00004139162,0.0001891432,0.00006711733,0.9910219,0.00003576395,0.00195506,0.0001937949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99338,0.005952855,0.00009554516,0.0001356291,0.00004687437,0.00009684987,0.00003332549,0.00001648736,0.0002424136],"genre_scores_gemma":[0.9979572,0.001041768,0.00007565202,0.00009628099,0.0001992144,0.00001943292,0.0004291144,0.00002064971,0.0001606859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004911087,"threshold_uncertainty_score":0.6883692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01586882695927483,"score_gpt":0.2448476829410652,"score_spread":0.2289788559817904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}