{"id":"W3213089913","doi":"10.3389/fncel.2021.768655","title":"Exploration of Aberrant E3 Ligases Implicated in Alzheimer’s Disease and Development of Chemical Tools to Modulate Their Function","year":2021,"lang":"en","type":"review","venue":"Frontiers in Cellular Neuroscience","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Genentech; National Institutes of Health; Innovative Medicines Initiative; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Novartis Pharma; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Pfizer","keywords":"Ubiquitin ligase; Ubiquitin; Downregulation and upregulation; Proteasome; Cell biology; Biology; Ubiquitin-Protein Ligases; Protein degradation; Computational biology; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002485282,0.0002260419,0.0005806925,0.0001525479,0.00002343891,0.00001822016,0.0002420668,0.0001390661,0.000001133762],"category_scores_gemma":[0.0001333192,0.0002059703,0.00008784275,0.0003592308,0.00009983065,0.00001414195,0.0002074175,0.0001139569,3.280846e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001864515,"about_ca_system_score_gemma":0.0003243856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002154233,"about_ca_topic_score_gemma":0.000001083898,"domain_scores_codex":[0.9983825,0.0001179189,0.0005480109,0.0005956572,0.0001472615,0.0002086246],"domain_scores_gemma":[0.9993172,0.00001094532,0.0002011755,0.0003198201,0.00004145682,0.0001094085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004180395,0.0001053228,0.00007077512,0.0009143412,0.00001549195,0.000007623715,0.00009876853,0.00003494414,0.4438405,0.000006563526,0.0000578037,0.5548061],"study_design_scores_gemma":[0.0002418101,0.0001243433,0.00009257462,0.001981205,0.00008238539,0.000003891026,0.00004442465,0.0001470534,0.7823249,0.00003769948,0.2144981,0.0004217149],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02852504,0.9595588,0.01075008,0.00001041116,0.0002826304,0.0007903915,0.00006643667,0.000004803695,0.00001140434],"genre_scores_gemma":[0.05987651,0.9360736,0.003220593,0.00006154216,0.00004471997,0.0002480683,0.0004131525,0.00004039284,0.00002142449],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5543843,"threshold_uncertainty_score":0.8399225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09143093192390822,"score_gpt":0.2931873706505734,"score_spread":0.2017564387266652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}