{"id":"W3213116899","doi":"10.1007/s12325-021-01944-y","title":"A Review of the Totality of Evidence for the Development and Approval of ABP 710 (AVSOLA), an Infliximab Biosimilar","year":2021,"lang":"en","type":"review","venue":"Advances in Therapy","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexus Clinical Research (Canada); Memorial University of Newfoundland","funders":"Amgen","keywords":"Infliximab; Medicine; Biosimilar; Rheumatoid arthritis; Pharmacology; Internal medicine; Monoclonal antibody; Tumor necrosis factor alpha; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007503351,0.001127158,0.003315328,0.00899177,0.0005699079,0.003047535,0.001785337,0.002617588,0.004024966],"category_scores_gemma":[0.02189608,0.0008840031,0.002833029,0.008732906,0.001040954,0.002587741,0.001088574,0.002575543,0.0009543302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002859255,"about_ca_system_score_gemma":0.008194039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002927181,"about_ca_topic_score_gemma":0.00627577,"domain_scores_codex":[0.9955447,0.0009999191,0.001807909,0.0004022858,0.001114657,0.0001305652],"domain_scores_gemma":[0.9742491,0.01693528,0.004268216,0.0003563416,0.003756766,0.0004343488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0004312236,0.00005412349,0.0007128013,0.378872,0.002145817,0.0003846819,0.0002345852,0.0002757549,0.0009424433,0.003287059,0.02570209,0.5869574],"study_design_scores_gemma":[0.0001316767,0.0003978625,0.004021838,0.4405691,0.009263439,0.001659683,0.0003431193,0.0001178058,0.000604542,0.002442002,0.5403884,0.00006057212],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001380268,0.9984237,0.00008895029,0.0006278144,0.0002014918,0.00001735167,0.00006697954,0.000003975689,0.0004317058],"genre_scores_gemma":[0.001787716,0.9966229,0.0003507352,0.0008497234,0.0001495426,0.0000291643,0.00009272693,0.000002632834,0.0001149902],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00899177,"threshold_uncertainty_score":0.03968197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2992263050150922,"score_gpt":0.4893622988553286,"score_spread":0.1901359938402364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}