{"id":"W3213145999","doi":"10.1182/blood-2021-147575","title":"RNA Binding Protein Syncrip Is Required for the Low-Output HSC By Sustaining Proteome Quality","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; BC Cancer Agency","funders":"","keywords":"Haematopoiesis; Stem cell; Biology; Transplantation; Bone marrow; Progenitor cell; Hematopoietic stem cell; Molecular biology; Leukemia; Myeloid leukemia; RNA-binding protein; Myeloid; Conditional gene knockout; RNA; Immunology; Cell biology; Cancer research; Genetics; Gene; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001666242,0.0003098031,0.0002474293,0.0002400537,0.0001759375,0.0004454829,0.0002545764,0.0003064487,0.002040241],"category_scores_gemma":[0.000121715,0.0001810462,0.0002003295,0.0001120813,0.0003122009,0.0001986752,0.0003536125,0.0006442103,0.0007814144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002454837,"about_ca_system_score_gemma":0.0001776645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000257334,"about_ca_topic_score_gemma":0.0005669103,"domain_scores_codex":[0.9997569,0.00002942171,0.00002672844,0.00006623319,0.00007315053,0.00004758852],"domain_scores_gemma":[0.9994156,0.00006565374,0.0002364589,0.00006492525,0.00003881888,0.0001784329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003662361,0.000006156293,0.0001414312,0.00001137122,0.000001185689,0.00004464417,0.000003982671,0.00001582709,0.9994183,0.00004748931,0.0000245918,0.000248534],"study_design_scores_gemma":[0.0000125789,0.00008280815,0.008655407,0.000007360906,0.00000808402,0.0005561836,0.00003321967,0.001015578,0.9875535,0.0000535174,0.002017666,0.000004012037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894912,0.001115379,0.006370304,0.0001548302,0.00002980549,0.00003223098,0.001299531,0.0002708189,0.001235726],"genre_scores_gemma":[0.9951457,0.0002009665,0.001846633,0.00006545516,0.000009032341,0.00002590344,0.0006874091,0.00008309742,0.001935655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002040241,"threshold_uncertainty_score":0.006825268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02529481596907268,"score_gpt":0.3052958475071119,"score_spread":0.2800010315380392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}