{"id":"W3213152445","doi":"10.3389/fonc.2021.761045","title":"Novel Nanoparticle-Based Cancer Treatment, Effectively Inhibits Lung Metastases and Improves Survival in a Murine Breast Cancer Model","year":2021,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Biodistribution; Toxicity; Medicine; Cancer; Breast cancer; Metastatic breast cancer; Adverse effect; Spleen; Lung cancer; Pharmacology; Cancer research; Internal medicine; Pathology; In vivo; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004906977,0.0003032106,0.0007240339,0.000229147,0.00007961686,0.00004712297,0.0001470513,0.0001457548,0.00008473802],"category_scores_gemma":[0.00008858272,0.0002833482,0.00006408369,0.0005247194,0.0002514499,0.0002829941,0.000116925,0.0001497213,0.000003998144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001577566,"about_ca_system_score_gemma":0.001338703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003569789,"about_ca_topic_score_gemma":0.01034269,"domain_scores_codex":[0.9975119,0.0003988836,0.0004528909,0.0007459424,0.0002029799,0.0006874235],"domain_scores_gemma":[0.9990567,0.0002507573,0.0001452944,0.0002652552,0.0001163004,0.0001656811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007859843,0.001229046,0.06570659,0.00005920863,0.00003534971,0.0001397646,0.0003352471,0.02046813,0.901184,0.00004323174,0.0002818758,0.00973153],"study_design_scores_gemma":[0.008679039,0.0002487634,0.01620352,0.000095357,0.0001135523,0.00002341087,0.0002419519,0.1353553,0.8384122,0.00009899291,0.0001656134,0.0003623166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910172,0.002940951,0.002587827,0.00123385,0.001084546,0.0004788944,0.0005699016,0.00005174955,0.0000350466],"genre_scores_gemma":[0.9905727,0.0002379676,0.008031202,0.0003678759,0.00007009007,0.0005881214,0.00001115874,0.0000355208,0.00008536111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1148871,"threshold_uncertainty_score":0.9999619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01666482534183085,"score_gpt":0.2871553298461024,"score_spread":0.2704905045042715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}