{"id":"W3213169138","doi":"10.1158/2767-9764.crc-21-0064","title":"BRCA1/ATF1-Mediated Transactivation is Involved in Resistance to PARP Inhibitors and Cisplatin","year":2021,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Kurozumi Medical Foundation; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Nakatomi Foundation","keywords":"Olaparib; Gene knockdown; Transactivation; Synthetic lethality; Poly ADP ribose polymerase; Cancer research; PARP inhibitor; Biology; Transcription factor; Molecular biology; RAD51; Homologous recombination; Chemistry; Cell culture; DNA repair; Gene; Genetics; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008964342,0.0001269913,0.0002561622,0.0003891871,0.0002826357,0.00005603537,0.0003067348,0.0001131553,0.0003067806],"category_scores_gemma":[0.0005140935,0.0001403482,0.00004339428,0.002161759,0.0002769283,0.0001705805,0.0001476449,0.0008022879,0.00003156882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007294873,"about_ca_system_score_gemma":0.0009295287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000448008,"about_ca_topic_score_gemma":0.009073807,"domain_scores_codex":[0.9977948,0.0004598708,0.000399804,0.0003822694,0.0005808022,0.0003824237],"domain_scores_gemma":[0.9968111,0.0005798679,0.00004650672,0.001470903,0.0008246051,0.0002670432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002305309,0.001736804,0.1030073,0.0008663411,0.0003682355,0.00009131743,0.03116702,0.0001470405,0.7200918,0.006804236,0.1009835,0.0324311],"study_design_scores_gemma":[0.01145177,0.0003139932,0.1030229,0.005215722,0.00005789809,0.00001634854,0.006760971,0.003612545,0.2063908,0.00617364,0.656085,0.0008984247],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7652189,0.01600545,0.0004985658,0.2090294,0.00009661501,0.001438314,0.000170764,0.00009255434,0.007449377],"genre_scores_gemma":[0.9835843,0.009919675,0.002013478,0.001996985,0.00006676238,0.001097654,0.0001087089,0.00003346755,0.001178905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5551016,"threshold_uncertainty_score":0.5723234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1630968270007572,"score_gpt":0.4551863214761788,"score_spread":0.2920894944754216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}