{"id":"W3213169138","doi":"10.1158/2767-9764.crc-21-0064","title":"BRCA1/ATF1-Mediated Transactivation is Involved in Resistance to PARP Inhibitors and Cisplatin","year":2021,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Kurozumi Medical Foundation; Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Nakatomi Foundation","keywords":"Olaparib; Gene knockdown; Transactivation; Synthetic lethality; Poly ADP ribose polymerase; Cancer research; PARP inhibitor; Biology; Transcription factor; Molecular biology; RAD51; Homologous recombination; Chemistry; Cell culture; DNA repair; Gene; Genetics; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000183811,0.0003347618,0.0004267543,0.0003685213,0.0001543389,0.0002952343,0.0001964385,0.0003259255,0.0007895675],"category_scores_gemma":[0.0002219012,0.0001785151,0.0003579558,0.0002229733,0.0001724168,0.0002610554,0.00014728,0.0004907923,0.0001939387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002465046,"about_ca_system_score_gemma":0.0001126904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003214148,"about_ca_topic_score_gemma":0.0002505102,"domain_scores_codex":[0.9997709,0.00003093491,0.00002997673,0.00005701217,0.00006385499,0.00004722312],"domain_scores_gemma":[0.9998326,0.00002183398,0.00007509696,0.00001728316,0.00002254676,0.00003059506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002340582,0.00004917839,0.003297386,0.00006863983,0.00001692956,0.0001304971,0.00002803281,0.0001463214,0.9913299,0.00006055805,0.00008731367,0.004551208],"study_design_scores_gemma":[0.00001806056,0.0004607101,0.092574,0.00001379765,0.00004719498,0.001518869,0.00006357729,0.001841132,0.9008519,0.0001286162,0.002466909,0.00001523703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919255,0.003980753,0.002463396,0.00009806356,0.00002337826,0.00003773465,0.0005440935,0.00009992133,0.0008271481],"genre_scores_gemma":[0.9970823,0.000860099,0.0007923176,0.00004475404,0.00000677909,0.00002510816,0.000510497,0.000008994935,0.000669026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007895675,"threshold_uncertainty_score":0.00264132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1630968270007572,"score_gpt":0.4551863214761788,"score_spread":0.2920894944754216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}