{"id":"W3213192832","doi":"10.1182/blood-2021-146397","title":"Real-World Efficacy and Safety Outcomes for Patients with Relapsed or Refractory (R/R) Aggressive B-Cell Non-Hodgkin's Lymphoma (aBNHL) Treated with Commercial Tisagenlecleucel: Update from the Center for International Blood and Marrow Transplant Research (CIBMTR) Registry","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Novartis (Canada); McMaster University; Juravinski Hospital","funders":"","keywords":"Medicine; Internal medicine; Cytokine release syndrome; Diffuse large B-cell lymphoma; Single Center; Oncology; Adverse effect; Aggressive lymphoma; Lymphoma; Surgery; Immunotherapy; Rituximab; Cancer; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002903047,0.0001901593,0.0005757306,0.000600743,0.0002975996,0.001348159,0.0005549843,0.0003482644,0.001325525],"category_scores_gemma":[0.004692296,0.0001396289,0.0007091881,0.001455899,0.000326711,0.0007483695,0.0004734884,0.0006385977,0.0004704144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001195283,"about_ca_system_score_gemma":0.0008472161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002815919,"about_ca_topic_score_gemma":0.006341854,"domain_scores_codex":[0.9986057,0.0004783534,0.0002218903,0.0002017294,0.0003805028,0.0001118829],"domain_scores_gemma":[0.992027,0.001453703,0.004233205,0.0004862469,0.001099927,0.0006999224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00828708,0.0002537749,0.9317304,0.000466395,0.0009964284,0.0001035822,0.0001529737,0.0006429115,0.0006466953,0.0002959375,0.00891895,0.0475049],"study_design_scores_gemma":[0.001078412,0.001712146,0.9817082,0.000175592,0.001105223,0.0006380677,0.0002516993,0.0008216472,0.0006271105,0.0003320239,0.01150552,0.0000442131],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9458107,0.00886224,0.0009220573,0.0009129451,0.00005640179,0.0002482768,0.03621105,0.00007272163,0.006903677],"genre_scores_gemma":[0.9563122,0.00230752,0.0008700061,0.0005945756,0.00009416042,0.0002967625,0.03896675,0.0000223981,0.0005356978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002903047,"threshold_uncertainty_score":0.01535296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02530467328569276,"score_gpt":0.3121794597627635,"score_spread":0.2868747864770707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}