{"id":"W3213196162","doi":"10.1182/blood-2021-144554","title":"Predictors for Improvement in Patient-Reported Outcomes: <i>Post-Hoc</i> Analysis of a Phase 3 Randomized, Open-Label Study of Eculizumab and Ravulizumab in Complement Inhibitor-Naïve Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Eculizumab; Internal medicine; Quality of life (healthcare); Post-hoc analysis; Physical therapy; Immunology; Complement system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01182198,0.001215736,0.002253003,0.000476956,0.0005584696,0.001229256,0.001211409,0.001225972,0.004233324],"category_scores_gemma":[0.008553861,0.0005481897,0.005568209,0.0004797342,0.0009774682,0.001475186,0.0009059056,0.002634766,0.0004342803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001145001,"about_ca_system_score_gemma":0.001705748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000805973,"about_ca_topic_score_gemma":0.001445731,"domain_scores_codex":[0.9907193,0.006378884,0.0004767432,0.001233571,0.0005808498,0.0006107312],"domain_scores_gemma":[0.9872422,0.0067598,0.002887062,0.0009551542,0.0008054288,0.001350392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9199507,0.006219291,0.04954222,0.000402252,0.01183176,0.00006753629,0.0001393379,0.001087832,0.002150861,0.00007290112,0.001110524,0.007424732],"study_design_scores_gemma":[0.2941325,0.2914327,0.376876,0.00009890213,0.02021531,0.0001836902,0.0002774946,0.01056046,0.003631023,0.0003418009,0.002115324,0.0001348078],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956322,0.0005876558,0.0005402933,0.000149074,0.00009839162,0.001181917,0.001209942,0.0000292877,0.0005712327],"genre_scores_gemma":[0.9948961,0.0001162515,0.000946881,0.0001955375,0.0001033754,0.001763142,0.001464178,0.00001444806,0.0004999907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01182198,"threshold_uncertainty_score":0.0625214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01586231829895645,"score_gpt":0.2840489322060092,"score_spread":0.2681866139070527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}