{"id":"W3213196162","doi":"10.1182/blood-2021-144554","title":"Predictors for Improvement in Patient-Reported Outcomes: <i>Post-Hoc</i> Analysis of a Phase 3 Randomized, Open-Label Study of Eculizumab and Ravulizumab in Complement Inhibitor-Naïve Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Eculizumab; Internal medicine; Quality of life (healthcare); Post-hoc analysis; Physical therapy; Immunology; Complement system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005545036,0.000356706,0.001960119,0.0004672145,0.00007524365,0.00002707523,0.0002849759,0.00009148524,0.0001358664],"category_scores_gemma":[0.0002222553,0.0002814413,0.000163483,0.0006597887,0.0001343724,0.0001204613,0.0004084113,0.0001297468,4.593668e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000835933,"about_ca_system_score_gemma":0.0002135261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000822282,"about_ca_topic_score_gemma":0.003028744,"domain_scores_codex":[0.9960573,0.0005702722,0.002123668,0.0006394849,0.0002053139,0.0004039789],"domain_scores_gemma":[0.9974391,0.0004278895,0.001081697,0.0005347442,0.0004628766,0.00005367129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.09721109,0.06684947,0.8070592,0.0002134295,0.01562823,0.00005304233,0.004157618,0.00003243898,0.00752525,0.00002859629,0.00005786568,0.001183752],"study_design_scores_gemma":[0.893658,0.008984169,0.07862627,0.0001634321,0.005617948,0.000005377198,0.005061315,0.0000335933,0.007471154,0.00001319711,0.00003613665,0.000329399],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918804,0.0005551971,0.0000232799,0.00002259866,0.0001611885,0.006343257,0.0009813205,0.00001256321,0.00002015844],"genre_scores_gemma":[0.9978465,0.000007582691,0.0001558631,0.0000396246,0.000004370699,0.0008029673,0.001106286,0.00002162315,0.00001518194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7964469,"threshold_uncertainty_score":0.9999638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01586231829895645,"score_gpt":0.2840489322060092,"score_spread":0.2681866139070527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}