{"id":"W3213227101","doi":"10.1182/blood-2021-145379","title":"Phase 3, Open-Label, Randomized Study of Gilteritinib and Azacitidine Vs Azacitidine for Newly Diagnosed <i>FLT3</i>-Mutated Acute Myeloid Leukemia in Patients Ineligible for Intensive Induction Chemotherapy","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Azacitidine; Myeloid leukemia; Medicine; Chemotherapy; Chemotherapy regimen; Induction chemotherapy; Internal medicine; Acute leukemia; Leukemia; Oncology; Biology; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002100094,0.001573278,0.003288322,0.0003836195,0.0005464077,0.001444278,0.001084546,0.001728071,0.006454368],"category_scores_gemma":[0.001499637,0.0007501635,0.002013873,0.0004277579,0.001639878,0.001491955,0.0004513369,0.005135312,0.001210135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001446008,"about_ca_system_score_gemma":0.002141031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001258326,"about_ca_topic_score_gemma":0.003697486,"domain_scores_codex":[0.9993466,0.0003117775,0.00003451265,0.0001179235,0.00004768281,0.000141593],"domain_scores_gemma":[0.9987003,0.0002842293,0.0002643798,0.00009414588,0.00006156364,0.0005953489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.973995,0.01304416,0.0009364093,0.0001654407,0.0004470278,0.00004496996,0.00004707789,0.0004098889,0.003407064,0.00007161475,0.0005800353,0.00685126],"study_design_scores_gemma":[0.8217698,0.1732961,0.002709389,0.00001527895,0.0003539062,0.00005014422,0.00002717289,0.0005446257,0.0005024419,0.0001454014,0.0005717972,0.00001387916],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902328,0.001427172,0.000444976,0.0005777841,0.0003140112,0.004240307,0.001103044,0.0001002467,0.001559639],"genre_scores_gemma":[0.9889451,0.0009330917,0.00127007,0.001036191,0.0003790981,0.004288333,0.001150487,0.00002509228,0.001972592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006454368,"threshold_uncertainty_score":0.02159202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03491268422275007,"score_gpt":0.3473118230856518,"score_spread":0.3123991388629018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}