{"id":"W3213227101","doi":"10.1182/blood-2021-145379","title":"Phase 3, Open-Label, Randomized Study of Gilteritinib and Azacitidine Vs Azacitidine for Newly Diagnosed <i>FLT3</i>-Mutated Acute Myeloid Leukemia in Patients Ineligible for Intensive Induction Chemotherapy","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Azacitidine; Myeloid leukemia; Medicine; Chemotherapy; Chemotherapy regimen; Induction chemotherapy; Internal medicine; Acute leukemia; Leukemia; Oncology; Biology; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000918283,0.000409014,0.001893208,0.0003839969,0.0001183779,0.00008099472,0.0002607358,0.0002099329,0.00003116293],"category_scores_gemma":[0.00227008,0.000366334,0.0001284204,0.0007771075,0.0001804742,0.000308859,0.0002355868,0.0003488309,0.000001580273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003037783,"about_ca_system_score_gemma":0.0007544098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000280593,"about_ca_topic_score_gemma":0.000061757,"domain_scores_codex":[0.9968365,0.0002465129,0.00110726,0.0008161234,0.0004068445,0.0005867548],"domain_scores_gemma":[0.9960709,0.0007146744,0.0003466987,0.0005001421,0.002133791,0.0002338584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.628468,0.0345191,0.006327803,0.0009337059,0.004298426,0.0004403902,0.005369193,0.000009383303,0.2979625,0.00008182158,0.005736644,0.01585303],"study_design_scores_gemma":[0.8208747,0.009124111,0.0009868135,0.0002587261,0.0008244772,0.00005476623,0.001413219,0.0006849595,0.1650456,0.0001311237,0.0002999773,0.0003015357],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860031,0.0001927934,0.0003113048,0.0009382216,0.0001337315,0.01199774,0.0003043012,0.00004885551,0.00006992868],"genre_scores_gemma":[0.9897819,0.0006019459,0.004391741,0.0009464337,0.0001635556,0.002458029,0.001194519,0.0001139408,0.0003479142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1924067,"threshold_uncertainty_score":0.9998789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03491268422275007,"score_gpt":0.3473118230856518,"score_spread":0.3123991388629018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}