{"id":"W3213232762","doi":"10.1016/j.jaad.2021.11.004","title":"Consistent safety profile with up to 5 years of continuous treatment with guselkumab: Pooled analyses from the phase 3 VOYAGE 1 and VOYAGE 2 trials of patients with moderate-to-severe psoriasis","year":2021,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research; Dalhousie University","funders":"Janssen Research and Development","keywords":"Medicine; Adverse effect; Psoriasis; Placebo; Dermatology; Randomized controlled trial; Crossover study; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01356529,0.001393071,0.0057133,0.000522804,0.000425787,0.002427188,0.0009564374,0.00178871,0.003880497],"category_scores_gemma":[0.01186379,0.0007351832,0.01373819,0.0009207437,0.000789965,0.002038141,0.0008161628,0.004246377,0.0005821219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007811733,"about_ca_system_score_gemma":0.000831241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007224972,"about_ca_topic_score_gemma":0.001566347,"domain_scores_codex":[0.9926273,0.004664456,0.0006431288,0.0009955717,0.0005804838,0.0004889597],"domain_scores_gemma":[0.9875496,0.006687168,0.002691424,0.00169026,0.0007824324,0.000599093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.7244987,0.0006646915,0.0250368,0.006700907,0.1596408,0.0001841273,0.0001874803,0.002494711,0.006126486,0.0003869568,0.004391292,0.06968695],"study_design_scores_gemma":[0.28068,0.08832706,0.2488017,0.00156047,0.3541648,0.0009160064,0.0003943399,0.002948605,0.003439271,0.002732655,0.0157229,0.0003121467],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7617159,0.2152054,0.005774813,0.001985901,0.001123534,0.0007675381,0.007372136,0.0002901336,0.005764623],"genre_scores_gemma":[0.9859567,0.007786979,0.0007735729,0.001235642,0.0004601296,0.000238618,0.002627785,0.00005895398,0.0008616589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01356529,"threshold_uncertainty_score":0.07174093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03140226911436131,"score_gpt":0.3067322821856013,"score_spread":0.2753300130712399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}