{"id":"W3213232762","doi":"10.1016/j.jaad.2021.11.004","title":"Consistent safety profile with up to 5 years of continuous treatment with guselkumab: Pooled analyses from the phase 3 VOYAGE 1 and VOYAGE 2 trials of patients with moderate-to-severe psoriasis","year":2021,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research; Dalhousie University","funders":"Janssen Research and Development","keywords":"Medicine; Adverse effect; Psoriasis; Placebo; Dermatology; Randomized controlled trial; Crossover study; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002188946,0.0002638006,0.001937547,0.0001610745,0.00008765948,0.000007781572,0.0002929746,0.0001087916,0.00006454142],"category_scores_gemma":[0.0001540301,0.0001241739,0.0002305978,0.0004457498,0.000563035,0.00005808513,0.00007511357,0.0001830149,0.000002355279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004360247,"about_ca_system_score_gemma":0.0002391847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001280195,"about_ca_topic_score_gemma":0.00003393879,"domain_scores_codex":[0.997152,0.001193537,0.001012544,0.0002458133,0.0001462964,0.0002498565],"domain_scores_gemma":[0.9962428,0.0008885932,0.002290721,0.0002665444,0.0002458607,0.00006553759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1856017,0.00395987,0.371637,0.0000952275,0.04647535,0.0002255448,0.00934605,0.0004943004,0.2789661,0.0001560195,0.003829588,0.09921329],"study_design_scores_gemma":[0.0419423,0.007214708,0.2837574,0.0004361305,0.008708987,0.001176028,0.004037969,0.000003996576,0.6479008,0.00003654087,0.004355295,0.0004298427],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950994,0.001555133,0.0001045084,0.001790635,0.00008615913,0.0005133513,0.0008170119,0.000004852973,0.00002893017],"genre_scores_gemma":[0.9980839,0.0002641847,0.001106346,0.0003317575,0.00001716499,0.00001501128,0.00002747072,0.0000197211,0.0001344284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3689347,"threshold_uncertainty_score":0.5063664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03140226911436131,"score_gpt":0.3067322821856013,"score_spread":0.2753300130712399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}