{"id":"W3213252676","doi":"10.25251/skin.5.supp.37","title":"Deucravacitinib, an Oral, Selective Tyrosine Kinase 2 (TYK2) Inhibitor, Compared With Placebo and Apremilast in Moderate to Severe Psoriasis: Integrated Laboratory Parameter Results From the Phase 3 POETYK PSO-1 and POETYK PSO-2 Trials","year":2021,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Bristol-Myers Squibb","keywords":"Apremilast; Placebo; Psoriasis; Medicine; Internal medicine; Pharmacology; Dermatology; Psoriatic arthritis; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004501353,0.000518708,0.001762393,0.0002378377,0.000211832,0.00007086105,0.0002208085,0.0002068051,0.00005364347],"category_scores_gemma":[0.006710214,0.0002529219,0.00007984627,0.0008070828,0.0004184852,0.0001906147,0.00006462297,0.001176734,0.000002793908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001687203,"about_ca_system_score_gemma":0.0006871087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002644749,"about_ca_topic_score_gemma":0.0009354929,"domain_scores_codex":[0.9943459,0.002339957,0.001551983,0.0004584101,0.0008284443,0.0004753178],"domain_scores_gemma":[0.9924342,0.004481523,0.0008431677,0.0005393377,0.001091935,0.00060986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5667415,0.002506216,0.004589205,0.0004151337,0.003171903,0.03013549,0.07827819,0.001478791,0.2146054,0.00006296755,0.06672315,0.03129201],"study_design_scores_gemma":[0.3760791,0.05101315,0.008789709,0.02496321,0.01021843,0.07604066,0.06673992,0.01436396,0.3364305,0.001555626,0.03071851,0.00308723],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988728,0.003549179,0.0001552905,0.00573117,0.0004363708,0.001060049,0.0002291403,0.00002661159,0.00008415289],"genre_scores_gemma":[0.9943176,0.0007635617,0.000990579,0.002525251,0.001164652,0.00001444408,0.00007965272,0.00006409761,0.00008014496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1906625,"threshold_uncertainty_score":0.9999923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0246529517252897,"score_gpt":0.2993854296567134,"score_spread":0.2747324779314237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}