{"id":"W3213267692","doi":"10.1016/j.eclinm.2021.101188","title":"Post-exposure Lopinavir-Ritonavir Prophylaxis versus Surveillance for Individuals Exposed to SARS-CoV-2: The COPEP Pragmatic Open-Label, Cluster Randomized Trial","year":2021,"lang":"en","type":"article","venue":"EClinicalMedicine","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"National Institute of Allergy and Infectious Diseases; Hôpitaux Universitaires de Genève; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Medicine; Lopinavir; Lopinavir/ritonavir; Pre-exposure prophylaxis; Randomized controlled trial; Open label; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Ritonavir; Coronavirus disease 2019 (COVID-19); Cluster (spacecraft); 2019-20 coronavirus outbreak; Post-exposure prophylaxis; Pediatrics; Virology; Internal medicine; Human immunodeficiency virus (HIV); Men who have sex with men; Antiretroviral therapy; Viral load; Outbreak","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003119303,0.002046661,0.003340093,0.0004457743,0.0004835132,0.001221361,0.0008911942,0.002167757,0.008747208],"category_scores_gemma":[0.004653824,0.0006460903,0.002764161,0.0004347219,0.001421222,0.001250575,0.0008082526,0.002218997,0.001017395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00101549,"about_ca_system_score_gemma":0.001693823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00136406,"about_ca_topic_score_gemma":0.001830481,"domain_scores_codex":[0.9980139,0.001325775,0.0001051674,0.0002583385,0.0001188524,0.0001780306],"domain_scores_gemma":[0.9981577,0.0006566059,0.0004532067,0.0001736806,0.0001391735,0.0004195508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9899941,0.002128132,0.0002388874,0.0006846049,0.0006189817,0.00002105392,0.00003380252,0.0001964959,0.0004524744,0.00009364282,0.000433531,0.005104267],"study_design_scores_gemma":[0.9774053,0.02073594,0.0006113243,0.00005620746,0.0002658099,0.00001531269,0.00001894188,0.0003239313,0.00006138504,0.0001947584,0.0003014411,0.000009779836],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9585834,0.006402151,0.001872019,0.002179995,0.001492201,0.02346164,0.001948845,0.0002077353,0.003852011],"genre_scores_gemma":[0.9592555,0.001954362,0.004567271,0.001986113,0.0006552652,0.02706063,0.00109322,0.0000365228,0.00339111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008747208,"threshold_uncertainty_score":0.02926236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.135520212745202,"score_gpt":0.4841954437496768,"score_spread":0.3486752310044748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}