{"id":"W3213267692","doi":"10.1016/j.eclinm.2021.101188","title":"Post-exposure Lopinavir-Ritonavir Prophylaxis versus Surveillance for Individuals Exposed to SARS-CoV-2: The COPEP Pragmatic Open-Label, Cluster Randomized Trial","year":2021,"lang":"en","type":"article","venue":"EClinicalMedicine","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"National Institute of Allergy and Infectious Diseases; Hôpitaux Universitaires de Genève; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Medicine; Lopinavir; Lopinavir/ritonavir; Pre-exposure prophylaxis; Randomized controlled trial; Open label; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Ritonavir; Coronavirus disease 2019 (COVID-19); Cluster (spacecraft); 2019-20 coronavirus outbreak; Post-exposure prophylaxis; Pediatrics; Virology; Internal medicine; Human immunodeficiency virus (HIV); Men who have sex with men; Antiretroviral therapy; Viral load; Outbreak","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.01662506,0.0005897465,0.00362514,0.0001536649,0.0004154909,0.0001642173,0.001209441,0.0004025842,0.0002200508],"category_scores_gemma":[0.4988475,0.0003469924,0.0005732804,0.001002745,0.001091973,0.000149711,0.001601527,0.001275023,0.0002171747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002035989,"about_ca_system_score_gemma":0.001805042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009518388,"about_ca_topic_score_gemma":0.0001415043,"domain_scores_codex":[0.9904777,0.002398269,0.002962749,0.001390249,0.001726365,0.001044705],"domain_scores_gemma":[0.845131,0.1488527,0.0007313855,0.00241272,0.002227552,0.0006446349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9489067,0.002200031,0.0005241535,0.0006792595,0.001403587,0.0001389871,0.0004575041,0.00000364359,0.002234772,0.0001632741,0.03182582,0.01146233],"study_design_scores_gemma":[0.8831857,0.02085358,0.0008198752,0.0006387993,0.0005082479,0.000006263273,0.0001598412,0.0002080177,0.0006528685,0.0004025206,0.09217848,0.0003858365],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5674888,0.002411757,0.002854624,0.3765892,0.005385185,0.04324952,0.0004532106,0.0002377751,0.001329961],"genre_scores_gemma":[0.8849624,0.001124166,0.009269805,0.08512648,0.004889231,0.006944316,0.0005986898,0.0001966373,0.006888249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4822225,"threshold_uncertainty_score":0.9998982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.135520212745202,"score_gpt":0.4841954437496768,"score_spread":0.3486752310044748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}