{"id":"W3213274906","doi":"10.1080/2162402x.2021.1995168","title":"Manufacturing T cells in hollow fiber membrane bioreactors changes their programming and enhances their potency","year":2021,"lang":"en","type":"article","venue":"OncoImmunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; McMaster University; TRIUMF","funders":"Canada Research Chairs","keywords":"Cryopreservation; Bioreactor; Cell; Cell culture; Chemistry; Cell biology; Biotechnology; Biology; Biochemistry; Embryo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003577817,0.0002688122,0.0001589337,0.0001221998,0.0001302453,0.0003839731,0.0002288948,0.0003193759,0.0006423968],"category_scores_gemma":[0.0003298875,0.0001064755,0.0003012786,0.00009464475,0.0002330047,0.0003162544,0.0002291239,0.0004982814,0.0003622917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002355179,"about_ca_system_score_gemma":0.0001940401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004104714,"about_ca_topic_score_gemma":0.0006457539,"domain_scores_codex":[0.9997548,0.00004932332,0.00002453628,0.00006045329,0.00006482093,0.00004594454],"domain_scores_gemma":[0.9997807,0.00005434416,0.00007776517,0.00003113268,0.00003509305,0.00002103579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002476349,0.000008619291,0.00009663995,0.00001082128,0.000001572565,0.00001580659,0.00001044752,0.0001198332,0.9989458,0.00004823914,0.00001387844,0.0007035649],"study_design_scores_gemma":[0.000002604033,0.00008212888,0.0003255824,0.000001906206,0.000003068951,0.00004783874,0.000007890431,0.0005196027,0.998343,0.00002197582,0.0006416457,0.000002793286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697683,0.0005743235,0.02758868,0.0001711683,0.00004077917,0.00004709692,0.000204569,0.0001989607,0.001406113],"genre_scores_gemma":[0.9683065,0.0003647456,0.02987407,0.00007841254,0.00001212641,0.00004680584,0.0001789712,0.00005519906,0.001083037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006423968,"threshold_uncertainty_score":0.002148986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02288096904731359,"score_gpt":0.2790658329351818,"score_spread":0.2561848638878682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}