{"id":"W3213306989","doi":"10.1182/blood-2021-145276","title":"A Phase 1/2 Study of Single Agent Tagraxofusp, a First-in-Class CD123-Targeted Therapy, in Patients with Myelofibrosis That Is Relapsed/Refractory Following JAK Inhibitor Therapy","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; Alberta Hospital Edmonton; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Myelofibrosis; Internal medicine; Constitutional symptoms; Refractory (planetary science); Ruxolitinib; Gastroenterology; Myeloid; Myeloproliferative neoplasm; Oncology; Bone marrow; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00171093,0.001544929,0.002009066,0.0003923371,0.000477885,0.00100437,0.0007926954,0.001415648,0.002821365],"category_scores_gemma":[0.0008441564,0.0006683341,0.001355453,0.0003568078,0.0008096706,0.0009912017,0.0002986658,0.002659385,0.0007641576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008491219,"about_ca_system_score_gemma":0.001581136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007482743,"about_ca_topic_score_gemma":0.001806409,"domain_scores_codex":[0.9995821,0.0001822093,0.00002294808,0.00008657131,0.00003797815,0.0000880447],"domain_scores_gemma":[0.9994226,0.00006832083,0.00008051303,0.00005572148,0.00004966655,0.0003232621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5771013,0.211069,0.01380073,0.0009952885,0.00200762,0.0009191089,0.0005526686,0.00301753,0.09355409,0.0004644089,0.007248373,0.08926991],"study_design_scores_gemma":[0.4622143,0.5168203,0.01287332,0.00002716574,0.0004830564,0.0004922181,0.00005713672,0.001204512,0.00312154,0.0001746905,0.002494022,0.00003770356],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925149,0.00113373,0.0005245788,0.0004432352,0.00009256029,0.003064018,0.001073333,0.0000614344,0.001092337],"genre_scores_gemma":[0.9867753,0.001204895,0.002343742,0.001128981,0.0001918123,0.003738355,0.002768878,0.00003180466,0.001816144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002821365,"threshold_uncertainty_score":0.009438396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02370567160200735,"score_gpt":0.2601668068438865,"score_spread":0.2364611352418791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}