{"id":"W3213322027","doi":"10.3390/v13112236","title":"HIV-1 Envelope Glycoproteins Proteolytic Cleavage Protects Infected Cells from ADCC Mediated by Plasma from Infected Individuals","year":2021,"lang":"en","type":"article","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Furin; Antibody-dependent cell-mediated cytotoxicity; Glycoprotein; Cleavage (geology); Epitope; Cell biology; Endoplasmic reticulum; Endocytic cycle; Chemistry; Viral envelope; Neutralizing antibody; Virology; Antibody; Biology; Virus; Molecular biology; Endocytosis; In vitro; Cell; Cytotoxicity; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000140744,0.0002047885,0.0002287504,0.00007704443,0.0001004105,0.0002280951,0.0001830918,0.0002557683,0.001291944],"category_scores_gemma":[0.0001780844,0.00009022979,0.0001130963,0.0000537227,0.0001323205,0.0001157457,0.0001527491,0.0004241394,0.0002009676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001098805,"about_ca_system_score_gemma":0.0001123372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002499898,"about_ca_topic_score_gemma":0.0002748755,"domain_scores_codex":[0.9998883,0.00003037875,0.000006982497,0.00001376967,0.00002693003,0.00003357223],"domain_scores_gemma":[0.9999291,0.0000213044,0.0000113796,0.00001299075,0.00001109847,0.00001422902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002457975,0.00005180955,0.0002732144,0.00002788917,0.000007747622,0.00004944466,0.00002191057,0.00006092304,0.9963571,0.0000571174,0.00004167726,0.002805311],"study_design_scores_gemma":[0.00006053836,0.001258717,0.008314942,0.00001177997,0.00001750799,0.0005461094,0.0000228275,0.0005875315,0.9876424,0.00008142102,0.001452396,0.000003879267],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973992,0.001041494,0.0007362328,0.00004381984,0.000009599373,0.00001825514,0.00007573555,0.00002126459,0.0006544219],"genre_scores_gemma":[0.9984087,0.0002443046,0.000426267,0.00003138398,0.000004634959,0.000009790728,0.0001240289,0.000003401872,0.0007474861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001291944,"threshold_uncertainty_score":0.004321933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01666439313829825,"score_gpt":0.2421549831654666,"score_spread":0.2254905900271683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}