{"id":"W3213330452","doi":"10.1053/j.gastro.2021.11.014","title":"An Integrated Taxonomy for Monogenic Inflammatory Bowel Disease","year":2021,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"UCB Pharma; Canadian Institutes of Health Research; Klarman Cell Observatory, Broad Institute; Charité – Universitätsmedizin Berlin; Deutsche Forschungsgemeinschaft; Manton Foundation; Medical Research Council; Biogen; Celgene; Howard Hughes Medical Institute; Kennedy Trust for Rheumatology Research; NIHR Oxford Biomedical Research Centre; Canada Excellence Research Chairs, Government of Canada; Wellcome Trust; Division of Diabetes, Endocrinology, and Metabolic Diseases; National Institute for Health and Care Research; Leona M. and Harry B. Helmsley Charitable Trust; Cystic Fibrosis Trust; National Institute of Diabetes and Digestive and Kidney Diseases; Amgen; Eli Lilly and Company","keywords":"Biology; Phenotype; Inflammatory bowel disease; Penetrance; Gene; Computational biology; Immune system; Genetics; Proteome; Disease; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002033745,0.001178778,0.001688158,0.007627058,0.00185059,0.00437032,0.001741568,0.002121578,0.004088281],"category_scores_gemma":[0.004869446,0.0002955911,0.001562874,0.004698131,0.003607739,0.00444709,0.003912742,0.00529518,0.002059893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002043542,"about_ca_system_score_gemma":0.003530258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003510759,"about_ca_topic_score_gemma":0.003430202,"domain_scores_codex":[0.9979326,0.0006498747,0.0004876815,0.0002390694,0.0003806306,0.0003102235],"domain_scores_gemma":[0.9967499,0.0007916298,0.0003903159,0.0003634813,0.00123178,0.0004728552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003272094,0.0002033043,0.03330071,0.001558908,0.0001914078,0.007938171,0.003891275,0.001574457,0.006419769,0.5475936,0.06946396,0.3275373],"study_design_scores_gemma":[0.00006088203,0.0003224187,0.0199402,0.001714197,0.0002014536,0.05827539,0.003660748,0.00386923,0.0007571109,0.3499923,0.5610579,0.0001482837],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.07208933,0.3232175,0.3509716,0.08289695,0.01660311,0.001051352,0.00479977,0.00228311,0.1460873],"genre_scores_gemma":[0.3663946,0.1564638,0.4019032,0.02050328,0.01315843,0.001362508,0.008895108,0.0005712116,0.03074774],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.007627058,"threshold_uncertainty_score":0.01482701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009273361652593685,"score_gpt":0.2290552323989483,"score_spread":0.2197818707463546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}