{"id":"W3213340689","doi":"10.1093/ajcn/nqab378","title":"Genosets for APOE and CYP7A1-rs3808607 variants do not predict LDL cholesterol lowering upon intervention with plant sterols in a randomized, double-blind, placebo-controlled trial","year":2021,"lang":"en","type":"article","venue":"American Journal of Clinical Nutrition","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"School of Global Policy and Strategy, University of California, San Diego; University of Manitoba","keywords":"Placebo; Cholesterol; Double blind; Randomized controlled trial; Internal medicine; Apolipoprotein E; Ldl cholesterol; Plant sterols; Medicine; Intervention (counseling); Endocrinology; Sterol; Psychiatry; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002284106,0.002344214,0.005636909,0.0004011459,0.000700638,0.001387901,0.001044457,0.003560998,0.007467101],"category_scores_gemma":[0.002796791,0.0009727417,0.003584529,0.0004539992,0.001911065,0.001555952,0.0005232258,0.004332557,0.001243028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005540304,"about_ca_system_score_gemma":0.0006163209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008849318,"about_ca_topic_score_gemma":0.001888348,"domain_scores_codex":[0.9990108,0.0004502647,0.00008848178,0.0002553531,0.00006801987,0.0001270554],"domain_scores_gemma":[0.998646,0.0005331368,0.0002697848,0.0001512316,0.0001183525,0.0002815868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9923057,0.0009726398,0.0004620308,0.0004752685,0.002331938,0.00002916405,0.00002500309,0.00004781811,0.000768485,0.00005740861,0.0002517144,0.002272785],"study_design_scores_gemma":[0.9702371,0.02313971,0.002317043,0.00006154275,0.003213268,0.00002575078,0.00003240095,0.0001835086,0.0001912091,0.0002030587,0.000375804,0.00001965299],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811046,0.01065492,0.0009172074,0.001332208,0.001877925,0.001493368,0.0008412295,0.0001448962,0.001633597],"genre_scores_gemma":[0.9897989,0.00311038,0.0009133113,0.001373633,0.0007980141,0.001133281,0.0007274009,0.00003085955,0.002114349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007467101,"threshold_uncertainty_score":0.02497989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0430466233919404,"score_gpt":0.3661576027461217,"score_spread":0.3231109793541813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}