{"id":"W3213371026","doi":"10.1182/blood-2021-148481","title":"Late vs Early Response and Depth of Response Are Associated with Improved Outcomes in Newly Diagnosed Multiple Myeloma (NDMM) Patients (pts) Treated with Ixazomib-Lenalidomide-Dexamethasone (IRd) or Placebo-Lenalidomide-Dexamethasone (pbo-Rd) in the Phase 3 TOURMALINE-MM2 Trial","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Queen Elizabeth II Health Sciences Centre; Institute of Cancer Research; University of Calgary; University of Alberta","funders":"","keywords":"Lenalidomide; Ixazomib; Dexamethasone; Multiple myeloma; Medicine; Internal medicine; Oncology; Placebo; Carfilzomib; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00197834,0.00037712,0.0006601621,0.0001278924,0.000123858,0.0005986237,0.0002935357,0.0003380527,0.00208626],"category_scores_gemma":[0.001385909,0.0001581328,0.001263719,0.0002615093,0.000254233,0.0003883551,0.0003076688,0.001089501,0.0001296212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004420714,"about_ca_system_score_gemma":0.0003572539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003630691,"about_ca_topic_score_gemma":0.001291664,"domain_scores_codex":[0.9994104,0.0003732332,0.00003512417,0.00008383546,0.00005575812,0.00004167536],"domain_scores_gemma":[0.9987901,0.0004122294,0.0005043588,0.00005365617,0.00004138012,0.0001982147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8050277,0.0023238,0.09877246,0.002518564,0.005919058,0.00007867195,0.0001640863,0.00173692,0.01071939,0.000239409,0.002378772,0.07012124],"study_design_scores_gemma":[0.2330277,0.1890979,0.5470825,0.0004800079,0.010337,0.0006916971,0.000170477,0.004527895,0.006387855,0.0009673475,0.007134099,0.00009537402],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922674,0.005537878,0.0002412828,0.0002379526,0.00004628646,0.0002349544,0.000784569,0.00001535539,0.000634259],"genre_scores_gemma":[0.9969004,0.0008825727,0.0004344096,0.0001914542,0.0000705413,0.0002992928,0.0006808823,0.00000477818,0.0005356608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00208626,"threshold_uncertainty_score":0.01046258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02882644790991139,"score_gpt":0.3007041714872035,"score_spread":0.2718777235772921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}